질소-인산전달계 최종 인산 수용체 EIIA^Ntr 조절의 다면성

The nitrogen-related phosphotransferase system (PTS^Ntr) is a secondary phosphorelay cascade system present in many Gramnegative bacteria. The primary sugar phosphotransferase (sugar-PTS) system has various physiological functions in bacteria based on carbon nutrients and their metabolites. Similarly, regulatory mechanisms of the PTS^Ntr also vary depending on the species. Recently, several studies have reported on the global regulation mechanism of EIIA^Ntr (encoded by ptsN), the final phosphate receptor of PTS^Ntr, involved in nitrogen/carbon metabolism, K⁺ concentration regulation, and virulence regulation. Depending on the diversity of strains with the corresponding systems, different phenotypes have been observed from regulation by EIIA^Ntr. Furthermore, since some of its regulatory mechanisms are yet to be discovered, the purpose of this review is to organize various phenotypes through the regulation of EIIA^Ntr based on environmental conditions across species, with updating recent findings on its mechanism.