14-3-3γ haploinsufficient mice display hyperactive and stress-sensitive behaviors

Do Eon Kim, Chang Hoon Cho, Kyoung Mi Sim, Osung Kwon, Eun Mi Hwang, Hyung Wook Kim, Jae Yong Park

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

14-3-3γ plays diverse roles in different aspects of cellular processes. Especially in the brain where 14-3-3γ is enriched, it has been reported to be involved in neurological and psychiatric diseases (e.g. Williams-Beuren syndrome and Creutzfeldt-Jakob disease). However, behavioral abnormalities related to 14-3-3γ deficiency are largely unknown. Here, by using 14-3-3γ deficient mice, we found that homozygous knockout mice were prenatally lethal, and heterozygous mice showed developmental delay relative to wild-type littermate mice. In addition, in behavioral analyses, we found that 14-3-3γ heterozygote mice display hyperactive and depressive-like behavior along with more sensitive responses to acute stress than littermate control mice. These results suggest that 14-3-3γ levels may be involved in the developmental manifestation of related neuropsychiatric diseases. In addition, 14-3-3γ heterozygote mice may be a potential model to study the molecular pathophysiology of neuropsychiatric symptoms.

Original languageEnglish
Pages (from-to)43-53
Number of pages11
JournalExperimental Neurobiology
Volume28
Issue number1
DOIs
Publication statusPublished - 2019

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation (NRF) of Korea (NRF-2016M3C7A1904149, NRF-2017M3A9C6027009 and NRF-2017M3A9C4092979 to JYP, NRF-2017R1D1A1B03032212 to C-HC, NRF-2016R1D-1A1B03933283 to HWK).

Publisher Copyright:
Copyright © Experimental Neurobiology 2019.

Keywords

  • 14-3-3γ
  • ADHD
  • Acute stress
  • Anxiety
  • Hyperactivity
  • Ywhag

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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