2-phenoxychromones and prenylflavonoids from Epimedium koreanum and their inhibitory effects on LPS-induced nitric oxide and interleukin-1β production

Qinghao Jin; Chul Lee; Jin Woo Lee; Eung Tae Yeon; Dongho Lee; Sang Bae Han; Jin Tae Hong; Youngsoo Kim; Mi Kyeong Lee; Bang Yeon Hwang

doi:10.1021/np400831p

2-phenoxychromones and prenylflavonoids from Epimedium koreanum and their inhibitory effects on LPS-induced nitric oxide and interleukin-1β production

Qinghao Jin, Chul Lee, Jin Woo Lee, Eung Tae Yeon, Dongho Lee, Sang Bae Han, Jin Tae Hong, Youngsoo Kim, Mi Kyeong Lee, Bang Yeon Hwang

Division of Biotechnology

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

Two new 2-phenoxychromones 1 and 2 and two prenylflavonoids 3 and 4 along with 12 known compounds (5-16) were isolated from the CH₂Cl ₂-soluble fraction of a methanol extract of Epimedium koreanum. Compounds 1, 4, 6, 7, 9, 10, 12, and 15 exhibit inhibitory effects on nitric oxide production with IC₅₀ values ranging from 16.8 to 49.3 μM. Compounds 1, 4, 7, and 12 also showed inhibitory effects on interleukin-1β production with IC₅₀ values ranging from 8.6 to 38.9 μM in RAW 264.7 macrophages.

Original language	English
Pages (from-to)	1724-1728
Number of pages	5
Journal	Journal of Natural Products
Volume	77
Issue number	7
DOIs	https://doi.org/10.1021/np400831p
Publication status	Published - 2014 Jul 25

ASJC Scopus subject areas

Molecular Medicine
Complementary and alternative medicine
Drug Discovery
Pharmacology
Pharmaceutical Science
Analytical Chemistry
Organic Chemistry

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10.1021/np400831p

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title = "2-phenoxychromones and prenylflavonoids from Epimedium koreanum and their inhibitory effects on LPS-induced nitric oxide and interleukin-1β production",

abstract = "Two new 2-phenoxychromones 1 and 2 and two prenylflavonoids 3 and 4 along with 12 known compounds (5-16) were isolated from the CH2Cl 2-soluble fraction of a methanol extract of Epimedium koreanum. Compounds 1, 4, 6, 7, 9, 10, 12, and 15 exhibit inhibitory effects on nitric oxide production with IC50 values ranging from 16.8 to 49.3 μM. Compounds 1, 4, 7, and 12 also showed inhibitory effects on interleukin-1β production with IC50 values ranging from 8.6 to 38.9 μM in RAW 264.7 macrophages.",

author = "Qinghao Jin and Chul Lee and Lee, {Jin Woo} and Yeon, {Eung Tae} and Dongho Lee and Han, {Sang Bae} and Hong, {Jin Tae} and Youngsoo Kim and Lee, {Mi Kyeong} and Hwang, {Bang Yeon}",

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doi = "10.1021/np400831p",

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T1 - 2-phenoxychromones and prenylflavonoids from Epimedium koreanum and their inhibitory effects on LPS-induced nitric oxide and interleukin-1β production

AU - Jin, Qinghao

AU - Lee, Chul

AU - Lee, Jin Woo

AU - Yeon, Eung Tae

AU - Lee, Dongho

AU - Han, Sang Bae

AU - Hong, Jin Tae

AU - Kim, Youngsoo

AU - Lee, Mi Kyeong

AU - Hwang, Bang Yeon

PY - 2014/7/25

Y1 - 2014/7/25

N2 - Two new 2-phenoxychromones 1 and 2 and two prenylflavonoids 3 and 4 along with 12 known compounds (5-16) were isolated from the CH2Cl 2-soluble fraction of a methanol extract of Epimedium koreanum. Compounds 1, 4, 6, 7, 9, 10, 12, and 15 exhibit inhibitory effects on nitric oxide production with IC50 values ranging from 16.8 to 49.3 μM. Compounds 1, 4, 7, and 12 also showed inhibitory effects on interleukin-1β production with IC50 values ranging from 8.6 to 38.9 μM in RAW 264.7 macrophages.

AB - Two new 2-phenoxychromones 1 and 2 and two prenylflavonoids 3 and 4 along with 12 known compounds (5-16) were isolated from the CH2Cl 2-soluble fraction of a methanol extract of Epimedium koreanum. Compounds 1, 4, 6, 7, 9, 10, 12, and 15 exhibit inhibitory effects on nitric oxide production with IC50 values ranging from 16.8 to 49.3 μM. Compounds 1, 4, 7, and 12 also showed inhibitory effects on interleukin-1β production with IC50 values ranging from 8.6 to 38.9 μM in RAW 264.7 macrophages.

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2-phenoxychromones and prenylflavonoids from Epimedium koreanum and their inhibitory effects on LPS-induced nitric oxide and interleukin-1β production

Abstract

ASJC Scopus subject areas

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