3D in vitro high throughput screening model for analysis of colorectal cancer organoid by radiotherapy and chemotherapy for precision medicine

Dong Hee Choi, Yong Hun Jung, Seung Chul Shin, Ji Hun Yang, Seok Chung

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    Organoids have been attracting much attention in precision medicine research because they are formed similar to structures and constructs of human tissues and possess most of the genetic data. However, there is a problem that the current method of organoid culture is not suitable for high throughput screening. In this study, a high throughput screening model using organoids was presented and several colorectal cancer were analyzed based on this. The responses of the organoids to radiotherapy and chemotherapy was analyzed using this model, and the results were consistent with the genetic data of the organoids.

    Original languageEnglish
    Title of host publication23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
    PublisherChemical and Biological Microsystems Society
    Pages420-421
    Number of pages2
    ISBN (Electronic)9781733419000
    Publication statusPublished - 2019
    Event23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019 - Basel, Switzerland
    Duration: 2019 Oct 272019 Oct 31

    Publication series

    Name23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019

    Conference

    Conference23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
    Country/TerritorySwitzerland
    CityBasel
    Period19/10/2719/10/31

    Bibliographical note

    Funding Information:
    This work was supported by the Technology Innovation Program (10067407, Development of high throughput organoid clearing system and 3D imaging system for drug) funded By the Ministry of Trade, industry & Energy(MOTIE, Korea)

    Publisher Copyright:
    © 2019 CBMS-0001.

    Keywords

    • Chemotherapy
    • High throughput screening
    • Organoid
    • Radiotherapy
    • Uniform

    ASJC Scopus subject areas

    • Bioengineering
    • Chemical Engineering (miscellaneous)

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