5-α Reductase inhibitory effect and astringent activity of green apple rind extract on human keratinocytes and fibroblast cells

Da Hee Son; Mi Hyun Nam; Chung Oui Hong; Hye Min Seol; Jae Eon Yang; Young Bu Kim; Cheong Tae Kim; Kwang Won Lee

doi:10.1271/bbb.120757

5-α Reductase inhibitory effect and astringent activity of green apple rind extract on human keratinocytes and fibroblast cells

Da Hee Son, Mi Hyun Nam, Chung Oui Hong, Hye Min Seol, Jae Eon Yang, Young Bu Kim, Cheong Tae Kim, Kwang Won Lee

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Unripe green apples contain condensed tannins at 10 times higher levels than ripe apples. Tannin not only has strong antioxidant activity, but also an astringent property. In this study, we investigated the effects of green apple rind (GAR) extracts in reducing facial pores and sebum secretion. Among the GAR extracts, the 70% ethanol GAR extract showed the highest antioxidant activity and tannin content. Hence, it was further fractionated with different solvents. Among these rind solvent fractions, the ethyl acetate fraction of the extract (GAR-E) showed astringent activity. Additionally, it exhibited inhibitory effects on 5-α reductase, and induced type 1 collagen and involucrin synthesis. These results suggest that GAR-E can be applied in cosmetics to reduce facial pore size and sebum secretion.

Original language	English
Pages (from-to)	714-721
Number of pages	8
Journal	Bioscience, Biotechnology and Biochemistry
Volume	77
Issue number	4
DOIs	https://doi.org/10.1271/bbb.120757
Publication status	Published - 2013

Bibliographical note

Funding Information:
This study was supported by the R&D Center of Ipeeres Ltd., 264-7 Gyerreukri, Miyangmyeon, An- seong, Gyeonggido, Republic of Korea. We thank the Korea University-CJ Food Safety Center (Seoul, Republic of Korea) for providing equipment and facilities.

Keywords

5-α reductase
Antioxidant
Facial pores
Green apple
Sebum

ASJC Scopus subject areas

General Medicine

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title = "5-α Reductase inhibitory effect and astringent activity of green apple rind extract on human keratinocytes and fibroblast cells",

abstract = "Unripe green apples contain condensed tannins at 10 times higher levels than ripe apples. Tannin not only has strong antioxidant activity, but also an astringent property. In this study, we investigated the effects of green apple rind (GAR) extracts in reducing facial pores and sebum secretion. Among the GAR extracts, the 70% ethanol GAR extract showed the highest antioxidant activity and tannin content. Hence, it was further fractionated with different solvents. Among these rind solvent fractions, the ethyl acetate fraction of the extract (GAR-E) showed astringent activity. Additionally, it exhibited inhibitory effects on 5-α reductase, and induced type 1 collagen and involucrin synthesis. These results suggest that GAR-E can be applied in cosmetics to reduce facial pore size and sebum secretion.",

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author = "Son, {Da Hee} and Nam, {Mi Hyun} and Hong, {Chung Oui} and Seol, {Hye Min} and Yang, {Jae Eon} and Kim, {Young Bu} and Kim, {Cheong Tae} and Lee, {Kwang Won}",

note = "Funding Information: This study was supported by the R&D Center of Ipeeres Ltd., 264-7 Gyerreukri, Miyangmyeon, An- seong, Gyeonggido, Republic of Korea. We thank the Korea University-CJ Food Safety Center (Seoul, Republic of Korea) for providing equipment and facilities.",

year = "2013",

doi = "10.1271/bbb.120757",

language = "English",

volume = "77",

pages = "714--721",

journal = "Bioscience, Biotechnology and Biochemistry",

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publisher = "Japan Society for Bioscience Biotechnology and Agrochemistry",

number = "4",

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TY - JOUR

T1 - 5-α Reductase inhibitory effect and astringent activity of green apple rind extract on human keratinocytes and fibroblast cells

AU - Son, Da Hee

AU - Nam, Mi Hyun

AU - Hong, Chung Oui

AU - Seol, Hye Min

AU - Yang, Jae Eon

AU - Kim, Young Bu

AU - Kim, Cheong Tae

AU - Lee, Kwang Won

N1 - Funding Information: This study was supported by the R&D Center of Ipeeres Ltd., 264-7 Gyerreukri, Miyangmyeon, An- seong, Gyeonggido, Republic of Korea. We thank the Korea University-CJ Food Safety Center (Seoul, Republic of Korea) for providing equipment and facilities.

PY - 2013

Y1 - 2013

N2 - Unripe green apples contain condensed tannins at 10 times higher levels than ripe apples. Tannin not only has strong antioxidant activity, but also an astringent property. In this study, we investigated the effects of green apple rind (GAR) extracts in reducing facial pores and sebum secretion. Among the GAR extracts, the 70% ethanol GAR extract showed the highest antioxidant activity and tannin content. Hence, it was further fractionated with different solvents. Among these rind solvent fractions, the ethyl acetate fraction of the extract (GAR-E) showed astringent activity. Additionally, it exhibited inhibitory effects on 5-α reductase, and induced type 1 collagen and involucrin synthesis. These results suggest that GAR-E can be applied in cosmetics to reduce facial pore size and sebum secretion.

AB - Unripe green apples contain condensed tannins at 10 times higher levels than ripe apples. Tannin not only has strong antioxidant activity, but also an astringent property. In this study, we investigated the effects of green apple rind (GAR) extracts in reducing facial pores and sebum secretion. Among the GAR extracts, the 70% ethanol GAR extract showed the highest antioxidant activity and tannin content. Hence, it was further fractionated with different solvents. Among these rind solvent fractions, the ethyl acetate fraction of the extract (GAR-E) showed astringent activity. Additionally, it exhibited inhibitory effects on 5-α reductase, and induced type 1 collagen and involucrin synthesis. These results suggest that GAR-E can be applied in cosmetics to reduce facial pore size and sebum secretion.

KW - 5-α reductase

KW - Antioxidant

KW - Facial pores

KW - Green apple

KW - Sebum

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DO - 10.1271/bbb.120757

M3 - Article

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AN - SCOPUS:84878784910

SN - 0916-8451

VL - 77

SP - 714

EP - 721

JO - Bioscience, Biotechnology and Biochemistry

JF - Bioscience, Biotechnology and Biochemistry

IS - 4

ER -

5-α Reductase inhibitory effect and astringent activity of green apple rind extract on human keratinocytes and fibroblast cells

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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