5-Fluorouracil, methotrexate, leucovorin, CDDP and epirubicin (FEPMTX): A wide-spectrum regimen of salvage chemotherapy for high-grade advanced gastric cancer

Kazuo Kinoshita; Yutaka Yonemura; Toshiharu Sawa; Tatsukazu Miyata; Hiroshi Sakuma; Nobuo Matsuki; Sigehiro Tanaka; Sachio Fushida; Takashi Fujimura; Young Jai Mok; Byung Sik Kim; Jong In Lee; Dong Wook Choi; Young Jin Song; Doo Hyun Yang; Sung Joon Kwon; Motohiro Tanaka; Itsuo Miyazaki

5-Fluorouracil, methotrexate, leucovorin, CDDP and epirubicin (FEPMTX): A wide-spectrum regimen of salvage chemotherapy for high-grade advanced gastric cancer

Kazuo Kinoshita, Yutaka Yonemura, Toshiharu Sawa, Tatsukazu Miyata, Hiroshi Sakuma, Nobuo Matsuki, Sigehiro Tanaka, Sachio Fushida, Takashi Fujimura, Young Jai Mok, Byung Sik Kim, Jong In Lee, Dong Wook Choi, Young Jin Song, Doo Hyun Yang, Sung Joon Kwon, Motohiro Tanaka, Itsuo Miyazaki

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Background/Aims: Twenty-one patients with primary stage IV gastric cancer were treated with a wide-spectrum regimen, designated as FEPMTX therapy to establish an effective salvage chemotherapy. Methodology: FEPMTX therapy consisted of 5-fluorouracil and the triple biochemical modulators in addition to epirubicin. The schedule comprised 3 days continuous administration of 5-fluorouracil (350mg/m2/day) and; methotrexate (MTX; 35mg/m²) on day 1, calcium leucovorin (LV; 30mg/m²) on day 2 and 3, cisplatin (CDDP; 30mg/m²) and epirubicin (20mg/m²) on day 3 every 2 weeks in principle. Results: Eleven partial responses, five no changes and five progressive diseases were obtained, and the response rate was 52%. Ten patients (partial response 7, no change 2, progressive disease 1) received gastrectomy (resectability rate 48%). The survival of responders was significantly longer than that of non-responders (median survival time, 356 days vs. 152 days) while there was no significant prolongation by resection of the primary lesion. Adverse effects such as myelosuppression, anorexia and fatigue sometimes occurred, but were mild and the regimen was well tolerated by all the patients. Conclusions: FEPMTX is thought to be an effective regimen for neoadjuvant chemotherapy with longer survival and little toxicity for patients with high-grade advanced gastric cancer.

Original language	English
Pages (from-to)	1716-1719
Number of pages	4
Journal	Hepato-gastroenterology
Volume	50
Issue number	53
Publication status	Published - 2003 Sept
Externally published	Yes

Keywords

Biochemical modulation
Gastric cancer
Salvage chemotherapy

ASJC Scopus subject areas

Hepatology
Gastroenterology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Kinoshita, K., Yonemura, Y., Sawa, T., Miyata, T., Sakuma, H., Matsuki, N., Tanaka, S., Fushida, S., Fujimura, T., Mok, Y. J., Kim, B. S., Lee, J. I., Choi, D. W., Song, Y. J., Yang, D. H., Kwon, S. J., Tanaka, M., & Miyazaki, I. (2003). 5-Fluorouracil, methotrexate, leucovorin, CDDP and epirubicin (FEPMTX): A wide-spectrum regimen of salvage chemotherapy for high-grade advanced gastric cancer. Hepato-gastroenterology, 50(53), 1716-1719.

Kinoshita, K, Yonemura, Y, Sawa, T, Miyata, T, Sakuma, H, Matsuki, N, Tanaka, S, Fushida, S, Fujimura, T, Mok, YJ, Kim, BS, Lee, JI, Choi, DW, Song, YJ, Yang, DH, Kwon, SJ, Tanaka, M & Miyazaki, I 2003, '5-Fluorouracil, methotrexate, leucovorin, CDDP and epirubicin (FEPMTX): A wide-spectrum regimen of salvage chemotherapy for high-grade advanced gastric cancer', Hepato-gastroenterology, vol. 50, no. 53, pp. 1716-1719.

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title = "5-Fluorouracil, methotrexate, leucovorin, CDDP and epirubicin (FEPMTX): A wide-spectrum regimen of salvage chemotherapy for high-grade advanced gastric cancer",

abstract = "Background/Aims: Twenty-one patients with primary stage IV gastric cancer were treated with a wide-spectrum regimen, designated as FEPMTX therapy to establish an effective salvage chemotherapy. Methodology: FEPMTX therapy consisted of 5-fluorouracil and the triple biochemical modulators in addition to epirubicin. The schedule comprised 3 days continuous administration of 5-fluorouracil (350mg/m2/day) and; methotrexate (MTX; 35mg/m2) on day 1, calcium leucovorin (LV; 30mg/m2) on day 2 and 3, cisplatin (CDDP; 30mg/m2) and epirubicin (20mg/m2) on day 3 every 2 weeks in principle. Results: Eleven partial responses, five no changes and five progressive diseases were obtained, and the response rate was 52%. Ten patients (partial response 7, no change 2, progressive disease 1) received gastrectomy (resectability rate 48%). The survival of responders was significantly longer than that of non-responders (median survival time, 356 days vs. 152 days) while there was no significant prolongation by resection of the primary lesion. Adverse effects such as myelosuppression, anorexia and fatigue sometimes occurred, but were mild and the regimen was well tolerated by all the patients. Conclusions: FEPMTX is thought to be an effective regimen for neoadjuvant chemotherapy with longer survival and little toxicity for patients with high-grade advanced gastric cancer.",

keywords = "Biochemical modulation, Gastric cancer, Salvage chemotherapy",

author = "Kazuo Kinoshita and Yutaka Yonemura and Toshiharu Sawa and Tatsukazu Miyata and Hiroshi Sakuma and Nobuo Matsuki and Sigehiro Tanaka and Sachio Fushida and Takashi Fujimura and Mok, {Young Jai} and Kim, {Byung Sik} and Lee, {Jong In} and Choi, {Dong Wook} and Song, {Young Jin} and Yang, {Doo Hyun} and Kwon, {Sung Joon} and Motohiro Tanaka and Itsuo Miyazaki",

year = "2003",

month = sep,

language = "English",

volume = "50",

pages = "1716--1719",

journal = "Hepato-gastroenterology",

issn = "0172-6390",

publisher = "H.G.E. Update Medical Publishing Ltd.",

number = "53",

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TY - JOUR

T1 - 5-Fluorouracil, methotrexate, leucovorin, CDDP and epirubicin (FEPMTX)

T2 - A wide-spectrum regimen of salvage chemotherapy for high-grade advanced gastric cancer

AU - Kinoshita, Kazuo

AU - Yonemura, Yutaka

AU - Sawa, Toshiharu

AU - Miyata, Tatsukazu

AU - Sakuma, Hiroshi

AU - Matsuki, Nobuo

AU - Tanaka, Sigehiro

AU - Fushida, Sachio

AU - Fujimura, Takashi

AU - Mok, Young Jai

AU - Kim, Byung Sik

AU - Lee, Jong In

AU - Choi, Dong Wook

AU - Song, Young Jin

AU - Yang, Doo Hyun

AU - Kwon, Sung Joon

AU - Tanaka, Motohiro

AU - Miyazaki, Itsuo

PY - 2003/9

Y1 - 2003/9

N2 - Background/Aims: Twenty-one patients with primary stage IV gastric cancer were treated with a wide-spectrum regimen, designated as FEPMTX therapy to establish an effective salvage chemotherapy. Methodology: FEPMTX therapy consisted of 5-fluorouracil and the triple biochemical modulators in addition to epirubicin. The schedule comprised 3 days continuous administration of 5-fluorouracil (350mg/m2/day) and; methotrexate (MTX; 35mg/m2) on day 1, calcium leucovorin (LV; 30mg/m2) on day 2 and 3, cisplatin (CDDP; 30mg/m2) and epirubicin (20mg/m2) on day 3 every 2 weeks in principle. Results: Eleven partial responses, five no changes and five progressive diseases were obtained, and the response rate was 52%. Ten patients (partial response 7, no change 2, progressive disease 1) received gastrectomy (resectability rate 48%). The survival of responders was significantly longer than that of non-responders (median survival time, 356 days vs. 152 days) while there was no significant prolongation by resection of the primary lesion. Adverse effects such as myelosuppression, anorexia and fatigue sometimes occurred, but were mild and the regimen was well tolerated by all the patients. Conclusions: FEPMTX is thought to be an effective regimen for neoadjuvant chemotherapy with longer survival and little toxicity for patients with high-grade advanced gastric cancer.

AB - Background/Aims: Twenty-one patients with primary stage IV gastric cancer were treated with a wide-spectrum regimen, designated as FEPMTX therapy to establish an effective salvage chemotherapy. Methodology: FEPMTX therapy consisted of 5-fluorouracil and the triple biochemical modulators in addition to epirubicin. The schedule comprised 3 days continuous administration of 5-fluorouracil (350mg/m2/day) and; methotrexate (MTX; 35mg/m2) on day 1, calcium leucovorin (LV; 30mg/m2) on day 2 and 3, cisplatin (CDDP; 30mg/m2) and epirubicin (20mg/m2) on day 3 every 2 weeks in principle. Results: Eleven partial responses, five no changes and five progressive diseases were obtained, and the response rate was 52%. Ten patients (partial response 7, no change 2, progressive disease 1) received gastrectomy (resectability rate 48%). The survival of responders was significantly longer than that of non-responders (median survival time, 356 days vs. 152 days) while there was no significant prolongation by resection of the primary lesion. Adverse effects such as myelosuppression, anorexia and fatigue sometimes occurred, but were mild and the regimen was well tolerated by all the patients. Conclusions: FEPMTX is thought to be an effective regimen for neoadjuvant chemotherapy with longer survival and little toxicity for patients with high-grade advanced gastric cancer.

KW - Biochemical modulation

KW - Gastric cancer

KW - Salvage chemotherapy

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M3 - Article

C2 - 14571825

AN - SCOPUS:10744226743

SN - 0172-6390

VL - 50

SP - 1716

EP - 1719

JO - Hepato-gastroenterology

JF - Hepato-gastroenterology

IS - 53

ER -

5-Fluorouracil, methotrexate, leucovorin, CDDP and epirubicin (FEPMTX): A wide-spectrum regimen of salvage chemotherapy for high-grade advanced gastric cancer

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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