Abstract
Due to the extremely low intensity contrast between the white matter (WM) and the gray matter (GM) at around 6 months of age (the isointense phase), it is difficult for manual annotation, hence the number of training labels is highly limited. Consequently, it is still challenging to automatically segment isointense infant brain MRI. Meanwhile, the contrast of intensity images in the early adult phase, such as 24 months of age, is a relatively better, which can be easily segmented by the well-developed tools, e.g., FreeSurfer. Therefore, the question is how could we employ these high-contrast images (such as 24-month-old images) to guide the segmentation of 6-month-old images. Motivated by the above purpose, we propose a method to explore the 24-month-old images for a reliable tissue segmentation of 6-month-old images. Specifically, we design a 3D-cycleGAN-Seg architecture to generate synthetic images of the isointense phase by transferring appearances between the two time-points. To guarantee the tissue segmentation consistency between 6-month-old and 24-month-old images, we employ features from generated segmentations to guide the training of the generator network. To further improve the quality of synthetic images, we propose a feature matching loss that computes the cosine distance between unpaired segmentation features of the real and fake images. Then, the transferred of 24-month-old images is used to jointly train the segmentation model on the 6-month-old images. Experimental results demonstrate a superior performance of the proposed method compared with the existing deep learning-based methods.
Original language | English |
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Title of host publication | Proceedings - International Symposium on Biomedical Imaging |
Publisher | IEEE Computer Society |
Pages | 359-362 |
Number of pages | 4 |
ISBN (Electronic) | 9781538693308 |
ISBN (Print) | 9781538693308 |
DOIs | |
Publication status | Published - 2020 Apr 1 |
Event | 17th IEEE International Symposium on Biomedical Imaging, ISBI 2020 - Iowa City, United States Duration: 2020 Apr 3 → 2020 Apr 7 |
Publication series
Name | Proceedings - International Symposium on Biomedical Imaging |
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Volume | 2020-April |
ISSN (Print) | 1945-7928 |
ISSN (Electronic) | 1945-8452 |
Conference
Conference | 17th IEEE International Symposium on Biomedical Imaging, ISBI 2020 |
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Country/Territory | United States |
City | Iowa City |
Period | 20/4/3 → 20/4/7 |
Bibliographical note
Publisher Copyright:© 2020 IEEE.
Keywords
- 6-month infant brain segmentation
- cy-cleGAN
- synthetic image
ASJC Scopus subject areas
- Biomedical Engineering
- Radiology Nuclear Medicine and imaging