7,10-Dihydroxy-8(E)-octadecenoic Acid Displays a Fungicidal Activity against Malassezia furfur

Hak Ryul Kim, In Hwan Kim

Research output: Contribution to journalComment/debatepeer-review

Abstract

Microbial conversion of some natural unsaturated fatty acids can produce polyhydroxy fatty acids, giving them new properties, such as higher viscosity and reactivity. Pseudomonas aeruginosa has been intensively studied to produce a novel 7,10-dihydroxy-8(E)-octadecenoic acid (DOD) from oleic acid and natural vegetable oils containing oleic acid. Recently, the antibacterial activities of DOD against food-borne pathogenic bacteria were reported; however, the action of such antibacterial properties against eucaryotic cells remains poorly known. In this study, we determined the antifungal activities of DOD against Malassezia furfur KCCM 12679 quantitatively and qualitatively. The antifungal activity of DOD against M. furfur KCCM 12679 was approximately five times higher than that of ketoconazole, a commercial antifungal agent. The MIC90 value of DOD against M. furfur KCCM 12679 was 50 µg/mL. In addition, we confirmed that the antifungal property of DOD was exerted through fungicidal activity.

Original languageEnglish
Pages (from-to)215-218
Number of pages4
JournalJournal of Oleo Science
Volume73
Issue number2
DOIs
Publication statusPublished - 2024

Bibliographical note

Publisher Copyright:
© 2024 by Japan Oil Chemists’ Society.

Keywords

  • 7,10-dihydroxy-8(E)-octadecenoic acid
  • antifungal activity
  • bioconversion
  • Malassezia furfur
  • Pseudomonas aeruginosa
  • vegetable oil

ASJC Scopus subject areas

  • General Chemistry
  • General Chemical Engineering

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