8-Oxoguanine: from oxidative damage to epigenetic and epitranscriptional modification

Ja Young Hahm; Jongyeun Park; Eun Sook Jang; Sung Wook Chi

doi:10.1038/s12276-022-00822-z

8-Oxoguanine: from oxidative damage to epigenetic and epitranscriptional modification

Ja Young Hahm, Jongyeun Park, Eun Sook Jang, Sung Wook Chi

Research output: Contribution to journal › Review article › peer-review

29 Citations (Scopus)

Abstract

In pathophysiology, reactive oxygen species control diverse cellular phenotypes by oxidizing biomolecules. Among these, the guanine base in nucleic acids is the most vulnerable to producing 8-oxoguanine, which can pair with adenine. Because of this feature, 8-oxoguanine in DNA (8-oxo-dG) induces a G > T (C > A) mutation in cancers, which can be deleterious and thus actively repaired by DNA repair pathways. 8-Oxoguanine in RNA (o⁸G) causes problems in aberrant quality and translational fidelity, thereby it is subjected to the RNA decay pathway. In addition to oxidative damage, 8-oxo-dG serves as an epigenetic modification that affects transcriptional regulatory elements and other epigenetic modifications. With the ability of o⁸G•A in base pairing, o⁸G alters structural and functional RNA–RNA interactions, enabling redirection of posttranscriptional regulation. Here, we address the production, regulation, and function of 8-oxo-dG and o⁸G under oxidative stress. Primarily, we focus on the epigenetic and epitranscriptional roles of 8-oxoguanine, which highlights the significance of oxidative modification in redox-mediated control of gene expression.

Original language	English
Pages (from-to)	1626-1642
Number of pages	17
Journal	Experimental and Molecular Medicine
Volume	54
Issue number	10
DOIs	https://doi.org/10.1038/s12276-022-00822-z
Publication status	Published - 2022 Oct

Bibliographical note

Funding Information:
We apologize to the researchers whose studies were not cited in this review because of space limitations. This work was supported by grants from the NRF funded by the Ministry of Science, ICT & Future Planning (2021R1C1C2094136, to J.Y.H.; (NRF-2020R1A2C3013762, to S.W.C.), from Korea University, and from the KU-KIST Graduate School of Converging Science and Technology Program.

Publisher Copyright:
© 2022, The Author(s).

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Clinical Biochemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/s12276-022-00822-z

Cite this

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abstract = "In pathophysiology, reactive oxygen species control diverse cellular phenotypes by oxidizing biomolecules. Among these, the guanine base in nucleic acids is the most vulnerable to producing 8-oxoguanine, which can pair with adenine. Because of this feature, 8-oxoguanine in DNA (8-oxo-dG) induces a G > T (C > A) mutation in cancers, which can be deleterious and thus actively repaired by DNA repair pathways. 8-Oxoguanine in RNA (o8G) causes problems in aberrant quality and translational fidelity, thereby it is subjected to the RNA decay pathway. In addition to oxidative damage, 8-oxo-dG serves as an epigenetic modification that affects transcriptional regulatory elements and other epigenetic modifications. With the ability of o8G•A in base pairing, o8G alters structural and functional RNA–RNA interactions, enabling redirection of posttranscriptional regulation. Here, we address the production, regulation, and function of 8-oxo-dG and o8G under oxidative stress. Primarily, we focus on the epigenetic and epitranscriptional roles of 8-oxoguanine, which highlights the significance of oxidative modification in redox-mediated control of gene expression.",

author = "Hahm, {Ja Young} and Jongyeun Park and Jang, {Eun Sook} and Chi, {Sung Wook}",

note = "Funding Information: We apologize to the researchers whose studies were not cited in this review because of space limitations. This work was supported by grants from the NRF funded by the Ministry of Science, ICT & Future Planning (2021R1C1C2094136, to J.Y.H.; (NRF-2020R1A2C3013762, to S.W.C.), from Korea University, and from the KU-KIST Graduate School of Converging Science and Technology Program. Publisher Copyright: {\textcopyright} 2022, The Author(s).",

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AU - Hahm, Ja Young

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AU - Chi, Sung Wook

N1 - Funding Information: We apologize to the researchers whose studies were not cited in this review because of space limitations. This work was supported by grants from the NRF funded by the Ministry of Science, ICT & Future Planning (2021R1C1C2094136, to J.Y.H.; (NRF-2020R1A2C3013762, to S.W.C.), from Korea University, and from the KU-KIST Graduate School of Converging Science and Technology Program. Publisher Copyright: © 2022, The Author(s).

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N2 - In pathophysiology, reactive oxygen species control diverse cellular phenotypes by oxidizing biomolecules. Among these, the guanine base in nucleic acids is the most vulnerable to producing 8-oxoguanine, which can pair with adenine. Because of this feature, 8-oxoguanine in DNA (8-oxo-dG) induces a G > T (C > A) mutation in cancers, which can be deleterious and thus actively repaired by DNA repair pathways. 8-Oxoguanine in RNA (o8G) causes problems in aberrant quality and translational fidelity, thereby it is subjected to the RNA decay pathway. In addition to oxidative damage, 8-oxo-dG serves as an epigenetic modification that affects transcriptional regulatory elements and other epigenetic modifications. With the ability of o8G•A in base pairing, o8G alters structural and functional RNA–RNA interactions, enabling redirection of posttranscriptional regulation. Here, we address the production, regulation, and function of 8-oxo-dG and o8G under oxidative stress. Primarily, we focus on the epigenetic and epitranscriptional roles of 8-oxoguanine, which highlights the significance of oxidative modification in redox-mediated control of gene expression.

AB - In pathophysiology, reactive oxygen species control diverse cellular phenotypes by oxidizing biomolecules. Among these, the guanine base in nucleic acids is the most vulnerable to producing 8-oxoguanine, which can pair with adenine. Because of this feature, 8-oxoguanine in DNA (8-oxo-dG) induces a G > T (C > A) mutation in cancers, which can be deleterious and thus actively repaired by DNA repair pathways. 8-Oxoguanine in RNA (o8G) causes problems in aberrant quality and translational fidelity, thereby it is subjected to the RNA decay pathway. In addition to oxidative damage, 8-oxo-dG serves as an epigenetic modification that affects transcriptional regulatory elements and other epigenetic modifications. With the ability of o8G•A in base pairing, o8G alters structural and functional RNA–RNA interactions, enabling redirection of posttranscriptional regulation. Here, we address the production, regulation, and function of 8-oxo-dG and o8G under oxidative stress. Primarily, we focus on the epigenetic and epitranscriptional roles of 8-oxoguanine, which highlights the significance of oxidative modification in redox-mediated control of gene expression.

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8-Oxoguanine: from oxidative damage to epigenetic and epitranscriptional modification

Abstract

Bibliographical note

ASJC Scopus subject areas

UN SDGs

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