A bioorthogonal ‘turn-on’ fluorescent probe for tracking mitochondrial nitroxyl formation

Kyoung Sunwoo, Kondapa Naidu Bobba, Ja Yun Lim, Taegun Park, Arup Podder, June Seok Heo, Seung Gwan Lee, Sankarprasad Bhuniya, Jong Seung Kim

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48 Citations (Scopus)


A bioreductant-resistant ‘turn-on’ chemodosimetric fluorescent probe Mito-1 has been developed for the detection of mitochondrial HNO in live cells. Mito-1 enables the detection of HNO as low as ∼18 nM. It has the capability to detect both exogenous and endogenous mitochondrial HNO formations in cellular milieus by providing fluorescence images. Its two-photon imaging ability fosters its use as a noninvasive imaging tool for the detection of mitochondrial nitroxyl.

Original languageEnglish
Pages (from-to)1723-1726
Number of pages4
JournalChemical Communications
Issue number10
Publication statusPublished - 2017

Bibliographical note

Funding Information:
This work was supported by CRI (No. 2009-0081566, JSK) project grants and GPF grant (No. 2014H1A2A1020978, KS) from the National Research Foundation of Korea. SB thanks DST-SERB, India, for a research grant (No. ECR/2015/00035, SB).

Publisher Copyright:
© The Royal Society of Chemistry.

Copyright 2020 Elsevier B.V., All rights reserved.

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • General Chemistry
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry


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