A bioorthogonal ‘turn-on’ fluorescent probe for tracking mitochondrial nitroxyl formation

Kyoung Sunwoo; Kondapa Naidu Bobba; Ja Yun Lim; Taegun Park; Arup Podder; June Seok Heo; Seung Gwan Lee; Sankarprasad Bhuniya; Jong Seung Kim

doi:10.1039/c6cc09082f

A bioorthogonal ‘turn-on’ fluorescent probe for tracking mitochondrial nitroxyl formation

Kyoung Sunwoo, Kondapa Naidu Bobba, Ja Yun Lim, Taegun Park, Arup Podder, June Seok Heo, Seung Gwan Lee, Sankarprasad Bhuniya, Jong Seung Kim

Research output: Contribution to journal › Article › peer-review

50 Citations (Scopus)

Abstract

A bioreductant-resistant ‘turn-on’ chemodosimetric fluorescent probe Mito-1 has been developed for the detection of mitochondrial HNO in live cells. Mito-1 enables the detection of HNO as low as ∼18 nM. It has the capability to detect both exogenous and endogenous mitochondrial HNO formations in cellular milieus by providing fluorescence images. Its two-photon imaging ability fosters its use as a noninvasive imaging tool for the detection of mitochondrial nitroxyl.

Original language	English
Pages (from-to)	1723-1726
Number of pages	4
Journal	Chemical Communications
Volume	53
Issue number	10
DOIs	https://doi.org/10.1039/c6cc09082f
Publication status	Published - 2017

Bibliographical note

Publisher Copyright:
© The Royal Society of Chemistry.

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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title = "A bioorthogonal {\textquoteleft}turn-on{\textquoteright} fluorescent probe for tracking mitochondrial nitroxyl formation",

abstract = "A bioreductant-resistant {\textquoteleft}turn-on{\textquoteright} chemodosimetric fluorescent probe Mito-1 has been developed for the detection of mitochondrial HNO in live cells. Mito-1 enables the detection of HNO as low as ∼18 nM. It has the capability to detect both exogenous and endogenous mitochondrial HNO formations in cellular milieus by providing fluorescence images. Its two-photon imaging ability fosters its use as a noninvasive imaging tool for the detection of mitochondrial nitroxyl.",

author = "Kyoung Sunwoo and Bobba, {Kondapa Naidu} and Lim, {Ja Yun} and Taegun Park and Arup Podder and Heo, {June Seok} and Lee, {Seung Gwan} and Sankarprasad Bhuniya and Kim, {Jong Seung}",

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T1 - A bioorthogonal ‘turn-on’ fluorescent probe for tracking mitochondrial nitroxyl formation

AU - Sunwoo, Kyoung

AU - Bobba, Kondapa Naidu

AU - Lim, Ja Yun

AU - Park, Taegun

AU - Podder, Arup

AU - Heo, June Seok

AU - Lee, Seung Gwan

AU - Bhuniya, Sankarprasad

AU - Kim, Jong Seung

PY - 2017

Y1 - 2017

N2 - A bioreductant-resistant ‘turn-on’ chemodosimetric fluorescent probe Mito-1 has been developed for the detection of mitochondrial HNO in live cells. Mito-1 enables the detection of HNO as low as ∼18 nM. It has the capability to detect both exogenous and endogenous mitochondrial HNO formations in cellular milieus by providing fluorescence images. Its two-photon imaging ability fosters its use as a noninvasive imaging tool for the detection of mitochondrial nitroxyl.

AB - A bioreductant-resistant ‘turn-on’ chemodosimetric fluorescent probe Mito-1 has been developed for the detection of mitochondrial HNO in live cells. Mito-1 enables the detection of HNO as low as ∼18 nM. It has the capability to detect both exogenous and endogenous mitochondrial HNO formations in cellular milieus by providing fluorescence images. Its two-photon imaging ability fosters its use as a noninvasive imaging tool for the detection of mitochondrial nitroxyl.

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U2 - 10.1039/c6cc09082f

DO - 10.1039/c6cc09082f

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SN - 1359-7345

VL - 53

SP - 1723

EP - 1726

JO - Chemical Communications

JF - Chemical Communications

IS - 10

ER -

A bioorthogonal ‘turn-on’ fluorescent probe for tracking mitochondrial nitroxyl formation

Abstract

Bibliographical note

ASJC Scopus subject areas

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