A bioorthogonal ‘turn-on’ fluorescent probe for tracking mitochondrial nitroxyl formation

Kyoung Sunwoo; Kondapa Naidu Bobba; Ja Yun Lim; Taegun Park; Arup Podder; June Seok Heo; Seung Gwan Lee; Sankarprasad Bhuniya; Jong Seung Kim

doi:10.1039/c6cc09082f

A bioorthogonal ‘turn-on’ fluorescent probe for tracking mitochondrial nitroxyl formation

Kyoung Sunwoo
, Kondapa Naidu Bobba
, Ja Yun Lim
, Taegun Park
, Arup Podder
, June Seok Heo
, Seung Gwan Lee^*
, Sankarprasad Bhuniya
, Jong Seung Kim

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

52 Citations (Scopus)

Abstract

A bioreductant-resistant ‘turn-on’ chemodosimetric fluorescent probe Mito-1 has been developed for the detection of mitochondrial HNO in live cells. Mito-1 enables the detection of HNO as low as ∼18 nM. It has the capability to detect both exogenous and endogenous mitochondrial HNO formations in cellular milieus by providing fluorescence images. Its two-photon imaging ability fosters its use as a noninvasive imaging tool for the detection of mitochondrial nitroxyl.

Original language	English
Pages (from-to)	1723-1726
Number of pages	4
Journal	Chemical Communications
Volume	53
Issue number	10
DOIs	https://doi.org/10.1039/c6cc09082f
Publication status	Published - 2017

Bibliographical note

Publisher Copyright:
© The Royal Society of Chemistry.

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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title = "A bioorthogonal {\textquoteleft}turn-on{\textquoteright} fluorescent probe for tracking mitochondrial nitroxyl formation",

abstract = "A bioreductant-resistant {\textquoteleft}turn-on{\textquoteright} chemodosimetric fluorescent probe Mito-1 has been developed for the detection of mitochondrial HNO in live cells. Mito-1 enables the detection of HNO as low as ∼18 nM. It has the capability to detect both exogenous and endogenous mitochondrial HNO formations in cellular milieus by providing fluorescence images. Its two-photon imaging ability fosters its use as a noninvasive imaging tool for the detection of mitochondrial nitroxyl.",

author = "Kyoung Sunwoo and Bobba, \{Kondapa Naidu\} and Lim, \{Ja Yun\} and Taegun Park and Arup Podder and Heo, \{June Seok\} and Lee, \{Seung Gwan\} and Sankarprasad Bhuniya and Kim, \{Jong Seung\}",

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doi = "10.1039/c6cc09082f",

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T1 - A bioorthogonal ‘turn-on’ fluorescent probe for tracking mitochondrial nitroxyl formation

AU - Sunwoo, Kyoung

AU - Bobba, Kondapa Naidu

AU - Lim, Ja Yun

AU - Park, Taegun

AU - Podder, Arup

AU - Heo, June Seok

AU - Lee, Seung Gwan

AU - Bhuniya, Sankarprasad

AU - Kim, Jong Seung

PY - 2017

Y1 - 2017

N2 - A bioreductant-resistant ‘turn-on’ chemodosimetric fluorescent probe Mito-1 has been developed for the detection of mitochondrial HNO in live cells. Mito-1 enables the detection of HNO as low as ∼18 nM. It has the capability to detect both exogenous and endogenous mitochondrial HNO formations in cellular milieus by providing fluorescence images. Its two-photon imaging ability fosters its use as a noninvasive imaging tool for the detection of mitochondrial nitroxyl.

AB - A bioreductant-resistant ‘turn-on’ chemodosimetric fluorescent probe Mito-1 has been developed for the detection of mitochondrial HNO in live cells. Mito-1 enables the detection of HNO as low as ∼18 nM. It has the capability to detect both exogenous and endogenous mitochondrial HNO formations in cellular milieus by providing fluorescence images. Its two-photon imaging ability fosters its use as a noninvasive imaging tool for the detection of mitochondrial nitroxyl.

UR - https://www.scopus.com/pages/publications/85011016401

U2 - 10.1039/c6cc09082f

DO - 10.1039/c6cc09082f

M3 - Article

C2 - 28106175

AN - SCOPUS:85011016401

SN - 1359-7345

VL - 53

SP - 1723

EP - 1726

JO - Chemical Communications

JF - Chemical Communications

IS - 10

ER -

A bioorthogonal ‘turn-on’ fluorescent probe for tracking mitochondrial nitroxyl formation

Abstract

Bibliographical note

ASJC Scopus subject areas

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