A biotin-guided fluorescent-peptide drug delivery system for cancer treatment

Taeyoung Kim, Hyun Mi Jeon, Hoa Thi Le, Tae Woo Kim, Chulhun Kang, Jong Seung Kim

    Research output: Contribution to journalArticlepeer-review

    55 Citations (Scopus)

    Abstract

    Herein, we present a fluorescent-peptide drug delivery system composed of biotin–naphthalimide–HJ inhibitor peptide2, prodrug 1. Treatment of 1 to biotin receptor-positive HepG2 cells, which are resistant to high concentrations of the HJ inhibitor peptide2, decreased cell viability and increased intracellular fluorescence.

    Original languageEnglish
    Pages (from-to)7690-7693
    Number of pages4
    JournalChemical Communications
    Volume50
    Issue number57
    DOIs
    Publication statusPublished - 2014 Jun 19

    ASJC Scopus subject areas

    • Electronic, Optical and Magnetic Materials
    • Catalysis
    • Ceramics and Composites
    • General Chemistry
    • Surfaces, Coatings and Films
    • Metals and Alloys
    • Materials Chemistry

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