A biotin-guided fluorescent-peptide drug delivery system for cancer treatment

Taeyoung Kim; Hyun Mi Jeon; Hoa Thi Le; Tae Woo Kim; Chulhun Kang; Jong Seung Kim

doi:10.1039/c4cc02878c

A biotin-guided fluorescent-peptide drug delivery system for cancer treatment

Taeyoung Kim, Hyun Mi Jeon, Hoa Thi Le, Tae Woo Kim, Chulhun Kang, Jong Seung Kim

Research output: Contribution to journal › Article › peer-review

50 Citations (Scopus)

Abstract

Herein, we present a fluorescent-peptide drug delivery system composed of biotin–naphthalimide–HJ inhibitor peptide2, prodrug 1. Treatment of 1 to biotin receptor-positive HepG2 cells, which are resistant to high concentrations of the HJ inhibitor peptide2, decreased cell viability and increased intracellular fluorescence.

Original language	English
Pages (from-to)	7690-7693
Number of pages	4
Journal	Chemical Communications
Volume	50
Issue number	57
DOIs	https://doi.org/10.1039/c4cc02878c
Publication status	Published - 2014 Jun 19

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Ceramics and Composites
Metals and Alloys
Materials Chemistry
Surfaces, Coatings and Films
Chemistry(all)
Catalysis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1039/c4cc02878c

Cite this

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title = "A biotin-guided fluorescent-peptide drug delivery system for cancer treatment",

abstract = "Herein, we present a fluorescent-peptide drug delivery system composed of biotin–naphthalimide–HJ inhibitor peptide2, prodrug 1. Treatment of 1 to biotin receptor-positive HepG2 cells, which are resistant to high concentrations of the HJ inhibitor peptide2, decreased cell viability and increased intracellular fluorescence.",

author = "Taeyoung Kim and Jeon, {Hyun Mi} and Le, {Hoa Thi} and Kim, {Tae Woo} and Chulhun Kang and Kim, {Jong Seung}",

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T1 - A biotin-guided fluorescent-peptide drug delivery system for cancer treatment

AU - Kim, Taeyoung

AU - Jeon, Hyun Mi

AU - Le, Hoa Thi

AU - Kim, Tae Woo

AU - Kang, Chulhun

AU - Kim, Jong Seung

PY - 2014/6/19

Y1 - 2014/6/19

N2 - Herein, we present a fluorescent-peptide drug delivery system composed of biotin–naphthalimide–HJ inhibitor peptide2, prodrug 1. Treatment of 1 to biotin receptor-positive HepG2 cells, which are resistant to high concentrations of the HJ inhibitor peptide2, decreased cell viability and increased intracellular fluorescence.

AB - Herein, we present a fluorescent-peptide drug delivery system composed of biotin–naphthalimide–HJ inhibitor peptide2, prodrug 1. Treatment of 1 to biotin receptor-positive HepG2 cells, which are resistant to high concentrations of the HJ inhibitor peptide2, decreased cell viability and increased intracellular fluorescence.

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U2 - 10.1039/c4cc02878c

DO - 10.1039/c4cc02878c

M3 - Article

C2 - 24898048

AN - SCOPUS:84903134707

SN - 1359-7345

VL - 50

SP - 7690

EP - 7693

JO - Chemical Communications

JF - Chemical Communications

IS - 57

ER -

A biotin-guided fluorescent-peptide drug delivery system for cancer treatment

Abstract

ASJC Scopus subject areas

UN SDGs

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