A biotin-guided formaldehyde sensor selectively detecting endogenous concentrations in cancerous cells and tissues

Yun Hak Lee; Yonghe Tang; Peter Verwilst; Weiying Lin; Jong Seung Kim

doi:10.1039/c6cc06158c

A biotin-guided formaldehyde sensor selectively detecting endogenous concentrations in cancerous cells and tissues

Yun Hak Lee, Yonghe Tang, Peter Verwilst, Weiying Lin, Jong Seung Kim

Research output: Contribution to journal › Article › peer-review

95 Citations (Scopus)

Abstract

A biotin appended formaldehyde sensor was found to specifically visualise both exogenous and endogenous levels of formaldehyde in biotin receptor positive cells over biotin negative cells by means of one- and two-photon excitation. The probe furthermore visualised endogenous levels of formaldehyde in tumour tissue slices up to 70 μm depth.

Original language	English
Pages (from-to)	11247-11250
Number of pages	4
Journal	Chemical Communications
Volume	52
Issue number	75
DOIs	https://doi.org/10.1039/c6cc06158c
Publication status	Published - 2016

Bibliographical note

Funding Information:
This work was supported by a CRI (No. 2009-0081566, JSK) project grant from the National Research Foundation of Korea, a Korea University grant (PV) and by National Natural Science Foundation of China grants (21172063, 21472067, WL), Taishan Scholar Foundation (TS 201511041, WL), and the start-up fund of the University of Jinan, China (WL).

Publisher Copyright:
© 2016 The Royal Society of Chemistry.

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c6cc06158c

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title = "A biotin-guided formaldehyde sensor selectively detecting endogenous concentrations in cancerous cells and tissues",

abstract = "A biotin appended formaldehyde sensor was found to specifically visualise both exogenous and endogenous levels of formaldehyde in biotin receptor positive cells over biotin negative cells by means of one- and two-photon excitation. The probe furthermore visualised endogenous levels of formaldehyde in tumour tissue slices up to 70 μm depth.",

author = "Lee, {Yun Hak} and Yonghe Tang and Peter Verwilst and Weiying Lin and Kim, {Jong Seung}",

note = "Funding Information: This work was supported by a CRI (No. 2009-0081566, JSK) project grant from the National Research Foundation of Korea, a Korea University grant (PV) and by National Natural Science Foundation of China grants (21172063, 21472067, WL), Taishan Scholar Foundation (TS 201511041, WL), and the start-up fund of the University of Jinan, China (WL). Publisher Copyright: {\textcopyright} 2016 The Royal Society of Chemistry.",

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AU - Lee, Yun Hak

AU - Tang, Yonghe

AU - Verwilst, Peter

AU - Lin, Weiying

AU - Kim, Jong Seung

N1 - Funding Information: This work was supported by a CRI (No. 2009-0081566, JSK) project grant from the National Research Foundation of Korea, a Korea University grant (PV) and by National Natural Science Foundation of China grants (21172063, 21472067, WL), Taishan Scholar Foundation (TS 201511041, WL), and the start-up fund of the University of Jinan, China (WL). Publisher Copyright: © 2016 The Royal Society of Chemistry.

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Y1 - 2016

N2 - A biotin appended formaldehyde sensor was found to specifically visualise both exogenous and endogenous levels of formaldehyde in biotin receptor positive cells over biotin negative cells by means of one- and two-photon excitation. The probe furthermore visualised endogenous levels of formaldehyde in tumour tissue slices up to 70 μm depth.

AB - A biotin appended formaldehyde sensor was found to specifically visualise both exogenous and endogenous levels of formaldehyde in biotin receptor positive cells over biotin negative cells by means of one- and two-photon excitation. The probe furthermore visualised endogenous levels of formaldehyde in tumour tissue slices up to 70 μm depth.

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U2 - 10.1039/c6cc06158c

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JO - Chemical Communications

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ER -

A biotin-guided formaldehyde sensor selectively detecting endogenous concentrations in cancerous cells and tissues

Abstract

Bibliographical note

ASJC Scopus subject areas

UN SDGs

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