A highly reactive and robust chiral Brønsted acid catalyst, chiral N-triflyl thiophosphoramide, was developed. The first metal-free Brønsted acid catalyzed enantioselective protonation reaction of silyl enol ethers was demonstrated using this chiral Brønsted acid catalyst. The catalyst loading could be reduced to 0.05 mol % without any deleterious effect on the enantioselectivity.
|Number of pages||2|
|Journal||Journal of the American Chemical Society|
|Publication status||Published - 2008 Jul 23|
ASJC Scopus subject areas
- Colloid and Surface Chemistry