A brønsted acid catalyst for the enantioselective protonation reaction

Hong Cheon Cheol, Hisashi Yamamoto

Research output: Contribution to journalArticlepeer-review

100 Citations (Scopus)


A highly reactive and robust chiral Brønsted acid catalyst, chiral N-triflyl thiophosphoramide, was developed. The first metal-free Brønsted acid catalyzed enantioselective protonation reaction of silyl enol ethers was demonstrated using this chiral Brønsted acid catalyst. The catalyst loading could be reduced to 0.05 mol % without any deleterious effect on the enantioselectivity.

Original languageEnglish
Pages (from-to)9246-9247
Number of pages2
JournalJournal of the American Chemical Society
Issue number29
Publication statusPublished - 2008 Jul 23
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry


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