A case of primary aldosteronism combined with acquired nephrogenic diabetes insipidus

Kitae Kim, Jae Hyoung Lee, Sun Chul Kim, Dae Ryong Cha, Young Sun Kang

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Aldosterone-producing adrenal adenoma can induce various clinical manifestations as a result of chronic exposure to aldosterone. We report a rare case of a 37-year-old man who complained of general weakness and polyuria. He was diagnosed with aldosterone-producing adrenal adenoma and nephrogenic diabetes insipidus. Aldosterone enhances the secretion of potassium in the collecting duct, which can lead to hypokalemia. By contrast, nephrogenic diabetes insipidus, which manifests as polyuria and polydipsia, can occur in several clinical conditions such as acquired tubular disease and those attributed to toxins and congenital causes. Among them, hypokalemia can also damage tubular structures in response to vasopressin. The patient's urine output was >3 L/d and was diluted. Owing to the ineffectiveness of vasopressin, we eventually made a diagnosis of nephrogenic diabetes insipidus. Laparoscopic adrenalectomy and intraoperative kidney biopsy were subsequently performed. The pathologic finding of kidney biopsy revealed a decrease in aquaporin-2 on immunohistochemical stain.

Original languageEnglish
Pages (from-to)229-233
Number of pages5
JournalKidney Research and Clinical Practice
Issue number4
Publication statusPublished - 2014 Dec 1
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2014. The Korean Society of Nephrology. Published by Elsevier. All rights reserved.


  • Aquaporin
  • Diabetes insipidus
  • Hyperaldosteronism
  • Hypokalemia

ASJC Scopus subject areas

  • Nephrology
  • Urology


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