A case of propylthiouracil induced diffuse pulmonary hemorrhage

Sung Yong Lee; Jin Yong Jung; Kyoung Ju Lee; Seung Hyeun Lee; Se Joong Kim; Eun Joo Lee; Gyu Young Hur; Hae Chul Jung; Sang Yeub Lee; Je Hyeong Kim; Chol Shin; Jae Jeong Shim; Kwang Ho In; Kyung Ho Kang; Se Hwa Yoo

doi:10.4046/trd.2005.58.1.78

A case of propylthiouracil induced diffuse pulmonary hemorrhage

Sung Yong Lee, Jin Yong Jung, Kyoung Ju Lee, Seung Hyeun Lee, Se Joong Kim, Eun Joo Lee, Gyu Young Hur, Hae Chul Jung, Sang Yeub Lee, Je Hyeong Kim, Chol Shin, Jae Jeong Shim, Kwang Ho In, Kyung Ho Kang, Se Hwa Yoo

Department of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Propylthiouracil(PUT) is a drug which used at Grave's disease. But PTU has recently been observed to associated with antineutrophil cytoplasmic antibody(ANCA)-positive vasculitis resulting in, infrequently, diffuse alveolar hemorrhage. We report the case of a patient who developed diffuse pulmonary hemorrhage after she had been taking PTU for two years. She had received a diagnosis of Grave's disease at two years ago. The serologic study was positive for ANCA with myeloperoxidase(MPO) specificity. Bronchoalveloar lavage(BAL) fluid analysis revealed hemosiderinladen macrophages. Such findings suggested propylthiouracil induced dffuse pulmonary hemorrhage associated with antineutrophil cytoplasmic antibody. To our knowledge, this represents the first documentation in a case of PTU-induced diffuse pulmonary hemorrhage in Korea.

Original language	English
Pages (from-to)	78-82
Number of pages	5
Journal	Tuberculosis and Respiratory Diseases
Volume	58
Issue number	1
DOIs	https://doi.org/10.4046/trd.2005.58.1.78
Publication status	Published - 2005 Jan

Keywords

ANCA
Diffuse alveolar hemorrhage
Propylthiouracil

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.4046/trd.2005.58.1.78

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title = "A case of propylthiouracil induced diffuse pulmonary hemorrhage",

abstract = "Propylthiouracil(PUT) is a drug which used at Grave's disease. But PTU has recently been observed to associated with antineutrophil cytoplasmic antibody(ANCA)-positive vasculitis resulting in, infrequently, diffuse alveolar hemorrhage. We report the case of a patient who developed diffuse pulmonary hemorrhage after she had been taking PTU for two years. She had received a diagnosis of Grave's disease at two years ago. The serologic study was positive for ANCA with myeloperoxidase(MPO) specificity. Bronchoalveloar lavage(BAL) fluid analysis revealed hemosiderinladen macrophages. Such findings suggested propylthiouracil induced dffuse pulmonary hemorrhage associated with antineutrophil cytoplasmic antibody. To our knowledge, this represents the first documentation in a case of PTU-induced diffuse pulmonary hemorrhage in Korea.",

keywords = "ANCA, Diffuse alveolar hemorrhage, Propylthiouracil",

author = "Lee, {Sung Yong} and Jung, {Jin Yong} and Lee, {Kyoung Ju} and Lee, {Seung Hyeun} and Kim, {Se Joong} and Lee, {Eun Joo} and Hur, {Gyu Young} and Jung, {Hae Chul} and Lee, {Sang Yeub} and Kim, {Je Hyeong} and Chol Shin and Shim, {Jae Jeong} and In, {Kwang Ho} and Kang, {Kyung Ho} and Yoo, {Se Hwa}",

year = "2005",

month = jan,

doi = "10.4046/trd.2005.58.1.78",

language = "English",

volume = "58",

pages = "78--82",

journal = "Tuberculosis and Respiratory Diseases",

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publisher = "The Korean Academy of Tuberculosis and Respiratory Diseases",

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AU - Lee, Sung Yong

AU - Jung, Jin Yong

AU - Lee, Kyoung Ju

AU - Lee, Seung Hyeun

AU - Kim, Se Joong

AU - Lee, Eun Joo

AU - Hur, Gyu Young

AU - Jung, Hae Chul

AU - Lee, Sang Yeub

AU - Kim, Je Hyeong

AU - Shin, Chol

AU - Shim, Jae Jeong

AU - In, Kwang Ho

AU - Kang, Kyung Ho

AU - Yoo, Se Hwa

PY - 2005/1

Y1 - 2005/1

N2 - Propylthiouracil(PUT) is a drug which used at Grave's disease. But PTU has recently been observed to associated with antineutrophil cytoplasmic antibody(ANCA)-positive vasculitis resulting in, infrequently, diffuse alveolar hemorrhage. We report the case of a patient who developed diffuse pulmonary hemorrhage after she had been taking PTU for two years. She had received a diagnosis of Grave's disease at two years ago. The serologic study was positive for ANCA with myeloperoxidase(MPO) specificity. Bronchoalveloar lavage(BAL) fluid analysis revealed hemosiderinladen macrophages. Such findings suggested propylthiouracil induced dffuse pulmonary hemorrhage associated with antineutrophil cytoplasmic antibody. To our knowledge, this represents the first documentation in a case of PTU-induced diffuse pulmonary hemorrhage in Korea.

AB - Propylthiouracil(PUT) is a drug which used at Grave's disease. But PTU has recently been observed to associated with antineutrophil cytoplasmic antibody(ANCA)-positive vasculitis resulting in, infrequently, diffuse alveolar hemorrhage. We report the case of a patient who developed diffuse pulmonary hemorrhage after she had been taking PTU for two years. She had received a diagnosis of Grave's disease at two years ago. The serologic study was positive for ANCA with myeloperoxidase(MPO) specificity. Bronchoalveloar lavage(BAL) fluid analysis revealed hemosiderinladen macrophages. Such findings suggested propylthiouracil induced dffuse pulmonary hemorrhage associated with antineutrophil cytoplasmic antibody. To our knowledge, this represents the first documentation in a case of PTU-induced diffuse pulmonary hemorrhage in Korea.

KW - ANCA

KW - Diffuse alveolar hemorrhage

KW - Propylthiouracil

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U2 - 10.4046/trd.2005.58.1.78

DO - 10.4046/trd.2005.58.1.78

M3 - Article

AN - SCOPUS:20244382117

SN - 1738-3536

VL - 58

SP - 78

EP - 82

JO - Tuberculosis and Respiratory Diseases

JF - Tuberculosis and Respiratory Diseases

IS - 1

ER -

A case of propylthiouracil induced diffuse pulmonary hemorrhage

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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