A case of syndrome of inappropriate secretion of antidiuretic hormone following chemotherapy in a patient with non-small-cell lung cancer

Kyoung Ju Lee; Jae Young Moon; Sung Yong Lee; Sang Yeub Lee; Je Hyeong Kim; Choi Shin; Jae Jeong Shim; Kwang Ho In; Kyung Ho Kang; Se Hwa Yoo

doi:10.4046/trd.2009.66.4.324

A case of syndrome of inappropriate secretion of antidiuretic hormone following chemotherapy in a patient with non-small-cell lung cancer

Kyoung Ju Lee, Jae Young Moon, Sung Yong Lee, Sang Yeub Lee, Je Hyeong Kim, Choi Shin, Jae Jeong Shim, Kwang Ho In, Kyung Ho Kang, Se Hwa Yoo

Department of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

The syndrome of inappropriate secretion of the antidiuretic hormone (SIADH) is a well recognized paraneoplastic phenomenon related to impaired water excretion, and can result in dilutional hyponatremia as well as central nervous system symptoms. It is characterized by a decrease in plasma osmolarity with inappropriately concentrated urine. The causes of SIADH are associated with pulmonary and endocrine disorders, central nervous system diseases, and malignancies, including lung cancer. The other causes of SIADH include some drugs, particularly chemotherapy agents. Anticancer drugs, such as cisplatin, vincristine, and cyclophosphamide are well known causes of SIADH but the mechanisms are unclear. Recently, we encountered a patient with advanced non-small cell lung cancer who suffered from general weakness and altered mentality after an intravenous carboplatin and gemcitabine combination.

Original language	English
Pages (from-to)	324-328
Number of pages	5
Journal	Tuberculosis and Respiratory Diseases
Volume	66
Issue number	4
DOIs	https://doi.org/10.4046/trd.2009.66.4.324
Publication status	Published - 2009 Apr

Keywords

Carboplatin
Hyponatremia
Inappropriate ADH syndrome
Non-small-cell lung carcinoma

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.4046/trd.2009.66.4.324

Cite this

@article{10fe24201ab24ae09c45b213124919a6,

title = "A case of syndrome of inappropriate secretion of antidiuretic hormone following chemotherapy in a patient with non-small-cell lung cancer",

abstract = "The syndrome of inappropriate secretion of the antidiuretic hormone (SIADH) is a well recognized paraneoplastic phenomenon related to impaired water excretion, and can result in dilutional hyponatremia as well as central nervous system symptoms. It is characterized by a decrease in plasma osmolarity with inappropriately concentrated urine. The causes of SIADH are associated with pulmonary and endocrine disorders, central nervous system diseases, and malignancies, including lung cancer. The other causes of SIADH include some drugs, particularly chemotherapy agents. Anticancer drugs, such as cisplatin, vincristine, and cyclophosphamide are well known causes of SIADH but the mechanisms are unclear. Recently, we encountered a patient with advanced non-small cell lung cancer who suffered from general weakness and altered mentality after an intravenous carboplatin and gemcitabine combination.",

keywords = "Carboplatin, Hyponatremia, Inappropriate ADH syndrome, Non-small-cell lung carcinoma",

author = "Lee, {Kyoung Ju} and Moon, {Jae Young} and Lee, {Sung Yong} and Lee, {Sang Yeub} and Kim, {Je Hyeong} and Choi Shin and Shim, {Jae Jeong} and In, {Kwang Ho} and Kang, {Kyung Ho} and Yoo, {Se Hwa}",

year = "2009",

month = apr,

doi = "10.4046/trd.2009.66.4.324",

language = "English",

volume = "66",

pages = "324--328",

journal = "Tuberculosis and Respiratory Diseases",

issn = "1738-3536",

publisher = "The Korean Academy of Tuberculosis and Respiratory Diseases",

number = "4",

}

TY - JOUR

T1 - A case of syndrome of inappropriate secretion of antidiuretic hormone following chemotherapy in a patient with non-small-cell lung cancer

AU - Lee, Kyoung Ju

AU - Moon, Jae Young

AU - Lee, Sung Yong

AU - Lee, Sang Yeub

AU - Kim, Je Hyeong

AU - Shin, Choi

AU - Shim, Jae Jeong

AU - In, Kwang Ho

AU - Kang, Kyung Ho

AU - Yoo, Se Hwa

PY - 2009/4

Y1 - 2009/4

N2 - The syndrome of inappropriate secretion of the antidiuretic hormone (SIADH) is a well recognized paraneoplastic phenomenon related to impaired water excretion, and can result in dilutional hyponatremia as well as central nervous system symptoms. It is characterized by a decrease in plasma osmolarity with inappropriately concentrated urine. The causes of SIADH are associated with pulmonary and endocrine disorders, central nervous system diseases, and malignancies, including lung cancer. The other causes of SIADH include some drugs, particularly chemotherapy agents. Anticancer drugs, such as cisplatin, vincristine, and cyclophosphamide are well known causes of SIADH but the mechanisms are unclear. Recently, we encountered a patient with advanced non-small cell lung cancer who suffered from general weakness and altered mentality after an intravenous carboplatin and gemcitabine combination.

AB - The syndrome of inappropriate secretion of the antidiuretic hormone (SIADH) is a well recognized paraneoplastic phenomenon related to impaired water excretion, and can result in dilutional hyponatremia as well as central nervous system symptoms. It is characterized by a decrease in plasma osmolarity with inappropriately concentrated urine. The causes of SIADH are associated with pulmonary and endocrine disorders, central nervous system diseases, and malignancies, including lung cancer. The other causes of SIADH include some drugs, particularly chemotherapy agents. Anticancer drugs, such as cisplatin, vincristine, and cyclophosphamide are well known causes of SIADH but the mechanisms are unclear. Recently, we encountered a patient with advanced non-small cell lung cancer who suffered from general weakness and altered mentality after an intravenous carboplatin and gemcitabine combination.

KW - Carboplatin

KW - Hyponatremia

KW - Inappropriate ADH syndrome

KW - Non-small-cell lung carcinoma

UR - http://www.scopus.com/inward/record.url?scp=67649337179&partnerID=8YFLogxK

U2 - 10.4046/trd.2009.66.4.324

DO - 10.4046/trd.2009.66.4.324

M3 - Article

AN - SCOPUS:67649337179

SN - 1738-3536

VL - 66

SP - 324

EP - 328

JO - Tuberculosis and Respiratory Diseases

JF - Tuberculosis and Respiratory Diseases

IS - 4

ER -

A case of syndrome of inappropriate secretion of antidiuretic hormone following chemotherapy in a patient with non-small-cell lung cancer

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this