A case of verrucous carcinoma improved by 5% imiquimod cream

Jun Ha Park, Hyo Hyun Ahn, Soo Nam Kim, Young Chul Kye

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    Verrucous carcinoma is a low grade, well differentiated, unusual variant of squamous cell carcinoma. It has been described to represent an intermediate lesion between condyloma acuminata and squamous cell carcinoma. Since malignant transformation of verrucous carcinoma has been reported to occur in 30-50% of cases, the first line treatment for verrucous carcinoma is surgery, preferably Mohs surgery. Herein, we describe a case of recurrent verrucous carcinoma on the right buttock of a man with a history of radical excision and radiotherapy of a previous perianal verrucous carcinoma. The patient was successfully treated with 5% imiquimod cream, an immune response modifier with potential antiviral and antitumor effects. Imiquimod may be an effective treatment for verrucous carcinoma and presents an alternative therapy to surgical excision.

    Original languageEnglish
    Pages (from-to)1568-1571
    Number of pages4
    JournalKorean Journal of Dermatology
    Issue number11
    Publication statusPublished - 2005 Nov


    • Giant condyloma acuminata of Buschke and Lowenstein
    • Imiquimod
    • Verrucus carcinoma

    ASJC Scopus subject areas

    • Dermatology


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