A chemodosimeter-modified carbon nanotube-field effect transistor: Toward a highly selective and sensitive electrical sensing platform

Chang Seuk Lee, Jong Seung Kim, Tae Hyun Kim

    Research output: Contribution to journalArticlepeer-review

    9 Citations (Scopus)

    Abstract

    We present a carbon nanotube-field effect transistor (CNT-FET) biosensor which first implements the chemodosimeter sensing principle in CNT nanoelectronics. We experimentally illustrate the specific molecular interplay that the cysteine-selective chemodosimeter immobilized on the CNT surface can specifically interact with cysteine, which leads to the chemical transformation of the chemodosimeter. Since the chemical transformation of the chemodosimeter can disrupt the charge distribution in the vicinity of the CNT surface, the carrier equilibrium in CNT might be altered, and manifested by the conductivity change of CNT-FET. The real-Time conductance measurements show our biosensor is capable of label-free, rapid, highly selective and ultrasensitive detection of cysteine with a detection limit down to 0.45 fM. These results first verify the signaling principle competency of chemical transformation of the chemodosimeter in CNT electronic sensors. Combined with the advantages of the highly selective chemodosimeter and sensitive CNT-FET, the excellent performance of our sensor indicates its promising prospect as a valuable tool for developing highly sensitive and selective sensing platforms in practical application.

    Original languageEnglish
    Pages (from-to)28414-28420
    Number of pages7
    JournalRSC Advances
    Volume9
    Issue number49
    DOIs
    Publication statusPublished - 2019

    Bibliographical note

    Publisher Copyright:
    © 2019 The Royal Society of Chemistry.

    ASJC Scopus subject areas

    • General Chemistry
    • General Chemical Engineering

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