A chemoselective cleavable fluorescence turn-ON linker for proteomic studies

Si Si Liew, Shubo Du, Jingyan Ge, Sijun Pan, Se Young Jang, Jun Seok Lee, Shao Q. Yao

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


We have developed a trifunctional cleavable fluorescence turn-ON linker for chemoproteomic applications. This novel linker, which became highly fluorescent only upon cleavage of the azo bond, was successfully used for in situ proteome profiling/target identification and studies on newly synthesised proteomes.

Original languageEnglish
Pages (from-to)13332-13335
Number of pages4
JournalChemical Communications
Issue number100
Publication statusPublished - 2017
Externally publishedYes

Bibliographical note

Funding Information:
Funding was provided by NMRC (CBRG/0038/2013), GSK-EDB Trust Fund (R-143-000-688-592), MOE-T1 (R-143-000-694-114) of Singapore, KIST (2E26110/CAP-16-02-KIST) and the Bio & Medical Technology Development Program of the National Research Foundation funded by the Ministry of Science, ICT & Future Planning (NRF-2016M3A9B6902060, NRF-2017M3A9D8029942) of Korea the and National Science Foundation of Zhejiang Province (LQ16B020003).

Publisher Copyright:
© 2017 The Royal Society of Chemistry.

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry


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