A chemoselective cleavable fluorescence turn-ON linker for proteomic studies

Si Si Liew; Shubo Du; Jingyan Ge; Sijun Pan; Se Young Jang; Jun Seok Lee; Shao Q. Yao

doi:10.1039/c7cc08235e

A chemoselective cleavable fluorescence turn-ON linker for proteomic studies

Si Si Liew, Shubo Du, Jingyan Ge, Sijun Pan, Se Young Jang, Jun Seok Lee, Shao Q. Yao

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

We have developed a trifunctional cleavable fluorescence turn-ON linker for chemoproteomic applications. This novel linker, which became highly fluorescent only upon cleavage of the azo bond, was successfully used for in situ proteome profiling/target identification and studies on newly synthesised proteomes.

Original language	English
Pages (from-to)	13332-13335
Number of pages	4
Journal	Chemical Communications
Volume	53
Issue number	100
DOIs	https://doi.org/10.1039/c7cc08235e
Publication status	Published - 2017
Externally published	Yes

Bibliographical note

Funding Information:
Funding was provided by NMRC (CBRG/0038/2013), GSK-EDB Trust Fund (R-143-000-688-592), MOE-T1 (R-143-000-694-114) of Singapore, KIST (2E26110/CAP-16-02-KIST) and the Bio & Medical Technology Development Program of the National Research Foundation funded by the Ministry of Science, ICT & Future Planning (NRF-2016M3A9B6902060, NRF-2017M3A9D8029942) of Korea the and National Science Foundation of Zhejiang Province (LQ16B020003).

Publisher Copyright:
© 2017 The Royal Society of Chemistry.

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c7cc08235e

Cite this

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title = "A chemoselective cleavable fluorescence turn-ON linker for proteomic studies",

abstract = "We have developed a trifunctional cleavable fluorescence turn-ON linker for chemoproteomic applications. This novel linker, which became highly fluorescent only upon cleavage of the azo bond, was successfully used for in situ proteome profiling/target identification and studies on newly synthesised proteomes.",

author = "Liew, {Si Si} and Shubo Du and Jingyan Ge and Sijun Pan and Jang, {Se Young} and Lee, {Jun Seok} and Yao, {Shao Q.}",

note = "Funding Information: Funding was provided by NMRC (CBRG/0038/2013), GSK-EDB Trust Fund (R-143-000-688-592), MOE-T1 (R-143-000-694-114) of Singapore, KIST (2E26110/CAP-16-02-KIST) and the Bio & Medical Technology Development Program of the National Research Foundation funded by the Ministry of Science, ICT & Future Planning (NRF-2016M3A9B6902060, NRF-2017M3A9D8029942) of Korea the and National Science Foundation of Zhejiang Province (LQ16B020003). Publisher Copyright: {\textcopyright} 2017 The Royal Society of Chemistry.",

year = "2017",

doi = "10.1039/c7cc08235e",

language = "English",

volume = "53",

pages = "13332--13335",

journal = "Chemical Communications",

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publisher = "Royal Society of Chemistry",

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T1 - A chemoselective cleavable fluorescence turn-ON linker for proteomic studies

AU - Liew, Si Si

AU - Du, Shubo

AU - Ge, Jingyan

AU - Pan, Sijun

AU - Jang, Se Young

AU - Lee, Jun Seok

AU - Yao, Shao Q.

N1 - Funding Information: Funding was provided by NMRC (CBRG/0038/2013), GSK-EDB Trust Fund (R-143-000-688-592), MOE-T1 (R-143-000-694-114) of Singapore, KIST (2E26110/CAP-16-02-KIST) and the Bio & Medical Technology Development Program of the National Research Foundation funded by the Ministry of Science, ICT & Future Planning (NRF-2016M3A9B6902060, NRF-2017M3A9D8029942) of Korea the and National Science Foundation of Zhejiang Province (LQ16B020003). Publisher Copyright: © 2017 The Royal Society of Chemistry.

PY - 2017

Y1 - 2017

N2 - We have developed a trifunctional cleavable fluorescence turn-ON linker for chemoproteomic applications. This novel linker, which became highly fluorescent only upon cleavage of the azo bond, was successfully used for in situ proteome profiling/target identification and studies on newly synthesised proteomes.

AB - We have developed a trifunctional cleavable fluorescence turn-ON linker for chemoproteomic applications. This novel linker, which became highly fluorescent only upon cleavage of the azo bond, was successfully used for in situ proteome profiling/target identification and studies on newly synthesised proteomes.

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DO - 10.1039/c7cc08235e

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SN - 1359-7345

VL - 53

SP - 13332

EP - 13335

JO - Chemical Communications

JF - Chemical Communications

IS - 100

ER -

A chemoselective cleavable fluorescence turn-ON linker for proteomic studies

Abstract

Bibliographical note

ASJC Scopus subject areas

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