A combination of lidocaine (lignocaine) and remifentanil reduces pain during propofol injection

Kyunghwa Kwak, Hoyun Chung, Choonhak Lim, Changgyu Han, Gwangwook Choi, Donggun Lim, Sioh Kim, Younghoon Jeon

    Research output: Contribution to journalArticlepeer-review

    5 Citations (Scopus)


    Objective: Pain on injection is a well known adverse effect of propofol. The purpose of this study was to compare the analgesic effect of a lidocaine (lignocaine)/remifentanil combination compared with either lidocaine alone or remifentanil alone during propofol injection for induction of anaesthesia. Methods: In a randomised, double-blind, prospective trial, 129 patients were allocated to one of three groups (each n = 43) receiving lidocaine 20mg, remifentanil 0.3 μg/kg or lidocaine 20mg plus remifentanil 0.3 μg/kg as pretreatment, followed by injection of 5mL of 1% propofol. Pain severity was evaluated on a four-point scale. Results: Two patients (4.7%) complained of pain in the lidocaine plus remifentanil group compared with 15 (35.7%) in the lidocaine alone group and 18 (42.9%) in the remifentanil alone group (p < 0.001). There was no significant difference in the incidence of injection pain between the lidocaine alone and remifentanil alone groups (p = 0.21). Conclusion: Pretreatment with a combination of lidocaine and remifentanil is more effective than either pretreatment alone in reducing pain on injection of propofol.

    Original languageEnglish
    Pages (from-to)493-497
    Number of pages5
    JournalClinical Drug Investigation
    Issue number7
    Publication statusPublished - 2007

    ASJC Scopus subject areas

    • Pharmacology (medical)


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