A comprehensive karyotypic analysis on a newly established sarcomatoid hepatocellular carcinoma cell line SH-J1 by comparative genomic hybridization and chromosome painting

Dae Ghon Kim; Soo Yeun Park; Hyun Kim; Yong Hyuck Chun; Woo Sung Moon; Sun-Hwa Park

doi:10.1016/S0165-4608(01)00543-X

A comprehensive karyotypic analysis on a newly established sarcomatoid hepatocellular carcinoma cell line SH-J1 by comparative genomic hybridization and chromosome painting

Dae Ghon Kim, Soo Yeun Park, Hyun Kim, Yong Hyuck Chun, Woo Sung Moon, Sun-Hwa Park

Department of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

We first established a sarcomatoid hepatocellular carcinoma cell line, designated as SH-J1, and applied comparative genomic hybridization and fluorescence in situ hybridization (FISH) with chromosome painting probes for the characterization of the chromosomal rearrangements. In the SH-J1 cell line, the pleomorphic spindle cells were arranged in bundles of interlacing patterns and were positive in immunohistochemical staining with hepatocyte-related markers. By G-banding and FISH, the chromosomal gains were detected at 6p and 17, whereas losses were observed at 3p21∼pter, 3q27∼qter, 4, 6q, 13pter∼q11, 16, 18, 19p13, and Y.

Original language	English
Pages (from-to)	120-124
Number of pages	5
Journal	Cancer Genetics and Cytogenetics
Volume	132
Issue number	2
DOIs	https://doi.org/10.1016/S0165-4608(01)00543-X
Publication status	Published - 2002 Jan 15

Bibliographical note

Funding Information:
This work was supported by Grant 2000-0-210-003-3 from the Basic Research Program of the Korea Science and Engineering Foundation.

ASJC Scopus subject areas

Molecular Biology
Genetics
Cancer Research

UN SDGs

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A comprehensive karyotypic analysis on a newly established sarcomatoid hepatocellular carcinoma cell line SH-J1 by comparative genomic hybridization and chromosome painting. / Kim, Dae Ghon; Park, Soo Yeun; Kim, Hyun et al.
In: Cancer Genetics and Cytogenetics, Vol. 132, No. 2, 15.01.2002, p. 120-124.

Research output: Contribution to journal › Article › peer-review

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abstract = "We first established a sarcomatoid hepatocellular carcinoma cell line, designated as SH-J1, and applied comparative genomic hybridization and fluorescence in situ hybridization (FISH) with chromosome painting probes for the characterization of the chromosomal rearrangements. In the SH-J1 cell line, the pleomorphic spindle cells were arranged in bundles of interlacing patterns and were positive in immunohistochemical staining with hepatocyte-related markers. By G-banding and FISH, the chromosomal gains were detected at 6p and 17, whereas losses were observed at 3p21∼pter, 3q27∼qter, 4, 6q, 13pter∼q11, 16, 18, 19p13, and Y.",

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A comprehensive karyotypic analysis on a newly established sarcomatoid hepatocellular carcinoma cell line SH-J1 by comparative genomic hybridization and chromosome painting

Abstract

Bibliographical note

ASJC Scopus subject areas

UN SDGs

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