TY - JOUR
T1 - A comprehensive karyotypic analysis on a newly established sarcomatoid hepatocellular carcinoma cell line SH-J1 by comparative genomic hybridization and chromosome painting
AU - Kim, Dae Ghon
AU - Park, Soo Yeun
AU - Kim, Hyun
AU - Chun, Yong Hyuck
AU - Moon, Woo Sung
AU - Park, Sun Hwa
N1 - Funding Information:
This work was supported by Grant 2000-0-210-003-3 from the Basic Research Program of the Korea Science and Engineering Foundation.
PY - 2002/1/15
Y1 - 2002/1/15
N2 - We first established a sarcomatoid hepatocellular carcinoma cell line, designated as SH-J1, and applied comparative genomic hybridization and fluorescence in situ hybridization (FISH) with chromosome painting probes for the characterization of the chromosomal rearrangements. In the SH-J1 cell line, the pleomorphic spindle cells were arranged in bundles of interlacing patterns and were positive in immunohistochemical staining with hepatocyte-related markers. By G-banding and FISH, the chromosomal gains were detected at 6p and 17, whereas losses were observed at 3p21∼pter, 3q27∼qter, 4, 6q, 13pter∼q11, 16, 18, 19p13, and Y.
AB - We first established a sarcomatoid hepatocellular carcinoma cell line, designated as SH-J1, and applied comparative genomic hybridization and fluorescence in situ hybridization (FISH) with chromosome painting probes for the characterization of the chromosomal rearrangements. In the SH-J1 cell line, the pleomorphic spindle cells were arranged in bundles of interlacing patterns and were positive in immunohistochemical staining with hepatocyte-related markers. By G-banding and FISH, the chromosomal gains were detected at 6p and 17, whereas losses were observed at 3p21∼pter, 3q27∼qter, 4, 6q, 13pter∼q11, 16, 18, 19p13, and Y.
UR - http://www.scopus.com/inward/record.url?scp=0037081848&partnerID=8YFLogxK
U2 - 10.1016/S0165-4608(01)00543-X
DO - 10.1016/S0165-4608(01)00543-X
M3 - Article
C2 - 11850072
AN - SCOPUS:0037081848
SN - 0165-4608
VL - 132
SP - 120
EP - 124
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
IS - 2
ER -