A concise synthesis of mupirocin H using a cross-metathesis-based strategy

Sandip Sengupta, Taebo Sim

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


A highly efficient (10.1% overall yield) and convergent (longest linear sequence of 16 steps) synthesis of mupirocin H has been achieved, starting from commercially available (+)-(R)-Roche ester. The route relies on an efficient Grubbs cross-metathesis reaction to generate a key, late-stage E-olefin intermediate, and a cobalt-catalysed diastereoselective Reformatsky reaction to produce a β-hydroxy ester that serves as a late-stage intermediate.

Original languageEnglish
Pages (from-to)5063-5070
Number of pages8
JournalEuropean Journal of Organic Chemistry
Issue number23
Publication statusPublished - 2014 Aug


  • Metathesis
  • Natural products
  • Polyketides
  • Reformatsky reaction
  • Total synthesis

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry


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