A coumarin-naphthalimide hybrid as a dual emissive fluorescent probe for hNQO1

Sun Young Park; Miae Won; Chulhun Kang; Jong Seung Kim; Min Hee Lee

doi:10.1016/j.dyepig.2019.01.050

A coumarin-naphthalimide hybrid as a dual emissive fluorescent probe for hNQO1

Sun Young Park, Miae Won, Chulhun Kang, Jong Seung Kim, Min Hee Lee

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

hNQO1 is a promising target for cancer diagnosis and treatment. Here, we developed a coumarin-naphthalimide hybrid (1) as a dual emissive fluorescent probe that enhances the emission through hNQO1-mediated cleavage of its trimethyl lockquinone moiety. Probe 1 can be used for a real-time monitoring of hNQO1 activity in living cells.

Original language	English
Pages (from-to)	341-345
Number of pages	5
Journal	Dyes and Pigments
Volume	164
DOIs	https://doi.org/10.1016/j.dyepig.2019.01.050
Publication status	Published - 2019 May

Bibliographical note

Funding Information:
This research was supported by the CRI project (2018R1A3B1052702, J.S.K.) and National Research Foundation of Korea (NRF) (2017R1D1A1B03030062, M.W.; 2017R1A2A2A05069805, C.K.; 2018R1C1B6006110, M.H.L.) and the Sookmyung Women's University BK21 Plus Scholarship.

Funding Information:
This research was supported by the CRI project ( 2018R1A3B1052702 , J.S.K.) and National Research Foundation of Korea (NRF) ( 2017R1D1A1B03030062 , M.W.; 2017R1A2A2A05069805 , C.K.; 2018R1C1B6006110 , M.H.L.) and the Sookmyung Women's University BK21 Plus Scholarship .

Publisher Copyright:
© 2019

Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.

Keywords

Coumarin
Dual emission imaging
Naphthalimide
hNQO1 detection

ASJC Scopus subject areas

Chemical Engineering(all)
Process Chemistry and Technology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.dyepig.2019.01.050

Cite this

@article{ef83a2198bb444359aee4f4c46f9ac20,

title = "A coumarin-naphthalimide hybrid as a dual emissive fluorescent probe for hNQO1",

abstract = "hNQO1 is a promising target for cancer diagnosis and treatment. Here, we developed a coumarin-naphthalimide hybrid (1) as a dual emissive fluorescent probe that enhances the emission through hNQO1-mediated cleavage of its trimethyl lockquinone moiety. Probe 1 can be used for a real-time monitoring of hNQO1 activity in living cells.",

keywords = "Coumarin, Dual emission imaging, Naphthalimide, hNQO1 detection",

author = "Park, {Sun Young} and Miae Won and Chulhun Kang and Kim, {Jong Seung} and Lee, {Min Hee}",

note = "Funding Information: This research was supported by the CRI project (2018R1A3B1052702, J.S.K.) and National Research Foundation of Korea (NRF) (2017R1D1A1B03030062, M.W.; 2017R1A2A2A05069805, C.K.; 2018R1C1B6006110, M.H.L.) and the Sookmyung Women's University BK21 Plus Scholarship. Funding Information: This research was supported by the CRI project ( 2018R1A3B1052702 , J.S.K.) and National Research Foundation of Korea (NRF) ( 2017R1D1A1B03030062 , M.W.; 2017R1A2A2A05069805 , C.K.; 2018R1C1B6006110 , M.H.L.) and the Sookmyung Women's University BK21 Plus Scholarship . Publisher Copyright: {\textcopyright} 2019 Copyright: Copyright 2019 Elsevier B.V., All rights reserved.",

year = "2019",

month = may,

doi = "10.1016/j.dyepig.2019.01.050",

language = "English",

volume = "164",

pages = "341--345",

journal = "Dyes and Pigments",

issn = "0143-7208",

publisher = "Elsevier BV",

}

TY - JOUR

T1 - A coumarin-naphthalimide hybrid as a dual emissive fluorescent probe for hNQO1

AU - Park, Sun Young

AU - Won, Miae

AU - Kang, Chulhun

AU - Kim, Jong Seung

AU - Lee, Min Hee

N1 - Funding Information: This research was supported by the CRI project (2018R1A3B1052702, J.S.K.) and National Research Foundation of Korea (NRF) (2017R1D1A1B03030062, M.W.; 2017R1A2A2A05069805, C.K.; 2018R1C1B6006110, M.H.L.) and the Sookmyung Women's University BK21 Plus Scholarship. Funding Information: This research was supported by the CRI project ( 2018R1A3B1052702 , J.S.K.) and National Research Foundation of Korea (NRF) ( 2017R1D1A1B03030062 , M.W.; 2017R1A2A2A05069805 , C.K.; 2018R1C1B6006110 , M.H.L.) and the Sookmyung Women's University BK21 Plus Scholarship . Publisher Copyright: © 2019 Copyright: Copyright 2019 Elsevier B.V., All rights reserved.

PY - 2019/5

Y1 - 2019/5

N2 - hNQO1 is a promising target for cancer diagnosis and treatment. Here, we developed a coumarin-naphthalimide hybrid (1) as a dual emissive fluorescent probe that enhances the emission through hNQO1-mediated cleavage of its trimethyl lockquinone moiety. Probe 1 can be used for a real-time monitoring of hNQO1 activity in living cells.

AB - hNQO1 is a promising target for cancer diagnosis and treatment. Here, we developed a coumarin-naphthalimide hybrid (1) as a dual emissive fluorescent probe that enhances the emission through hNQO1-mediated cleavage of its trimethyl lockquinone moiety. Probe 1 can be used for a real-time monitoring of hNQO1 activity in living cells.

KW - Coumarin

KW - Dual emission imaging

KW - Naphthalimide

KW - hNQO1 detection

UR - http://www.scopus.com/inward/record.url?scp=85060958906&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85060958906&partnerID=8YFLogxK

U2 - 10.1016/j.dyepig.2019.01.050

DO - 10.1016/j.dyepig.2019.01.050

M3 - Article

AN - SCOPUS:85060958906

SN - 0143-7208

VL - 164

SP - 341

EP - 345

JO - Dyes and Pigments

JF - Dyes and Pigments

ER -

A coumarin-naphthalimide hybrid as a dual emissive fluorescent probe for hNQO1

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this