A Cytotoxic Secocycloartenoid from Abies koreana

Hyun Jung Kim; Quoc Khanh Le; Mi Hyun Lee; Tae Sung Kim; Hyeong Kyu Lee; Young Ho Kim; Ki Hwan Bae; Ik Soo Lee

doi:10.1007/BF02975159

A Cytotoxic Secocycloartenoid from Abies koreana

Hyun Jung Kim, Quoc Khanh Le, Mi Hyun Lee, Tae Sung Kim, Hyeong Kyu Lee, Young Ho Kim, Ki Hwan Bae, Ik Soo Lee

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

Two triterpenoids, 24-methylene-3,4-seco-cycloart-4(28)-en-3-oic acid (1) and 3-oxo-9β- lanosta-7,22Z,24-trien-26,23-olide (6) were isolated from Abies koreana, together with β- sitosterol (2), maltol (3), β-sitosterol-O-β-D-glucoside (4), and hexacosylferulate (5). The structures of the compounds were established based on the spectroscopic data. The cytotoxic activities of triterpenoids have been evaluated using the sulforhodamine B (SRB) method. Compound 1 showed moderate cytotoxicities against human lung carcinoma (A549), ovarian carcinoma (SK-OV-3), malignant melanoma (SK-MEL-2), and colon carcinoma (HCT-15) cell lines.

Original language	English
Pages (from-to)	527-531
Number of pages	5
Journal	Archives of pharmacal research
Volume	24
Issue number	6
DOIs	https://doi.org/10.1007/BF02975159
Publication status	Published - 2001
Externally published	Yes

Keywords

24-methylene-3,4-seco-cycloart-4(28)-en-3-oic acid
3- Oxo-9β-lanosta-7,22z,24-trien-26,23-olide
Abies koreana
Cytotoxicity
Pinaceae

ASJC Scopus subject areas

Molecular Medicine
Drug Discovery
Organic Chemistry

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10.1007/BF02975159

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@article{3bc34ad22a3c49ed827447b0debc7301,

title = "A Cytotoxic Secocycloartenoid from Abies koreana",

abstract = "Two triterpenoids, 24-methylene-3,4-seco-cycloart-4(28)-en-3-oic acid (1) and 3-oxo-9β- lanosta-7,22Z,24-trien-26,23-olide (6) were isolated from Abies koreana, together with β- sitosterol (2), maltol (3), β-sitosterol-O-β-D-glucoside (4), and hexacosylferulate (5). The structures of the compounds were established based on the spectroscopic data. The cytotoxic activities of triterpenoids have been evaluated using the sulforhodamine B (SRB) method. Compound 1 showed moderate cytotoxicities against human lung carcinoma (A549), ovarian carcinoma (SK-OV-3), malignant melanoma (SK-MEL-2), and colon carcinoma (HCT-15) cell lines.",

keywords = "24-methylene-3,4-seco-cycloart-4(28)-en-3-oic acid, 3- Oxo-9β-lanosta-7,22z,24-trien-26,23-olide, Abies koreana, Cytotoxicity, Pinaceae",

author = "Kim, {Hyun Jung} and Le, {Quoc Khanh} and Lee, {Mi Hyun} and Kim, {Tae Sung} and Lee, {Hyeong Kyu} and Kim, {Young Ho} and Bae, {Ki Hwan} and Lee, {Ik Soo}",

note = "Funding Information: We thank the Kwangju Branch of Korea Basic Science Institute (KBSI) for running NMR experiments. This research was supported by a grant from Korea Science & Engineering Foundation (Grant No. 1999-1-216-001-3).",

year = "2001",

doi = "10.1007/BF02975159",

language = "English",

volume = "24",

pages = "527--531",

journal = "Archives of Pharmacal Research",

issn = "0253-6269",

publisher = "Pharmaceutical Society of Korea",

number = "6",

}

TY - JOUR

T1 - A Cytotoxic Secocycloartenoid from Abies koreana

AU - Kim, Hyun Jung

AU - Le, Quoc Khanh

AU - Lee, Mi Hyun

AU - Kim, Tae Sung

AU - Lee, Hyeong Kyu

AU - Kim, Young Ho

AU - Bae, Ki Hwan

AU - Lee, Ik Soo

N1 - Funding Information: We thank the Kwangju Branch of Korea Basic Science Institute (KBSI) for running NMR experiments. This research was supported by a grant from Korea Science & Engineering Foundation (Grant No. 1999-1-216-001-3).

PY - 2001

Y1 - 2001

N2 - Two triterpenoids, 24-methylene-3,4-seco-cycloart-4(28)-en-3-oic acid (1) and 3-oxo-9β- lanosta-7,22Z,24-trien-26,23-olide (6) were isolated from Abies koreana, together with β- sitosterol (2), maltol (3), β-sitosterol-O-β-D-glucoside (4), and hexacosylferulate (5). The structures of the compounds were established based on the spectroscopic data. The cytotoxic activities of triterpenoids have been evaluated using the sulforhodamine B (SRB) method. Compound 1 showed moderate cytotoxicities against human lung carcinoma (A549), ovarian carcinoma (SK-OV-3), malignant melanoma (SK-MEL-2), and colon carcinoma (HCT-15) cell lines.

AB - Two triterpenoids, 24-methylene-3,4-seco-cycloart-4(28)-en-3-oic acid (1) and 3-oxo-9β- lanosta-7,22Z,24-trien-26,23-olide (6) were isolated from Abies koreana, together with β- sitosterol (2), maltol (3), β-sitosterol-O-β-D-glucoside (4), and hexacosylferulate (5). The structures of the compounds were established based on the spectroscopic data. The cytotoxic activities of triterpenoids have been evaluated using the sulforhodamine B (SRB) method. Compound 1 showed moderate cytotoxicities against human lung carcinoma (A549), ovarian carcinoma (SK-OV-3), malignant melanoma (SK-MEL-2), and colon carcinoma (HCT-15) cell lines.

KW - 24-methylene-3,4-seco-cycloart-4(28)-en-3-oic acid

KW - 3- Oxo-9β-lanosta-7,22z,24-trien-26,23-olide

KW - Abies koreana

KW - Cytotoxicity

KW - Pinaceae

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U2 - 10.1007/BF02975159

DO - 10.1007/BF02975159

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SN - 0253-6269

VL - 24

SP - 527

EP - 531

JO - Archives of Pharmacal Research

JF - Archives of Pharmacal Research

IS - 6

ER -

A Cytotoxic Secocycloartenoid from Abies koreana

Abstract

Keywords

ASJC Scopus subject areas

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