A Double-Chambered Protein Nanocage Loaded with Thrombin Receptor Agonist Peptide (TRAP) and γ-Carboxyglutamic Acid of Protein C (PC-Gla) for Sepsis Treatment

Wonhwa Lee, Junyoung Seo, Soyoung Kwak, Eun Ji Park, Dong Hee Na, Soyoun Kim, You Mie Lee, In San Kim, Jong Sup Bae

    Research output: Contribution to journalArticlepeer-review

    36 Citations (Scopus)

    Abstract

    New protein nanocages are designed bearing two functional proteins, γ-carboxyglutamic acid of protein C (PC-Gla) and thrombin receptor agonist peptide (TRAP), and have an anti-septic response. These nanoparticles reduce sepsis-induced organ injury and septic mortality in vivo. Noting that there are currently no medications for severe sepsis, these results show that novel nanoparticles can be used to treat sepsis.

    Original languageEnglish
    Pages (from-to)6637-6643
    Number of pages7
    JournalAdvanced Materials
    Volume27
    Issue number42
    DOIs
    Publication statusPublished - 2015 Nov 1

    Bibliographical note

    Publisher Copyright:
    © 2015 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

    Keywords

    • PC-gla
    • TRAP
    • ferritin
    • nanoparticles
    • sepsis

    ASJC Scopus subject areas

    • General Materials Science
    • Mechanics of Materials
    • Mechanical Engineering

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