A Double-Chambered Protein Nanocage Loaded with Thrombin Receptor Agonist Peptide (TRAP) and γ-Carboxyglutamic Acid of Protein C (PC-Gla) for Sepsis Treatment

Wonhwa Lee; Junyoung Seo; Soyoung Kwak; Eun Ji Park; Dong Hee Na; Soyoun Kim; You Mie Lee; In-San Kim; Jong Sup Bae

doi:10.1002/adma.201503093

A Double-Chambered Protein Nanocage Loaded with Thrombin Receptor Agonist Peptide (TRAP) and γ-Carboxyglutamic Acid of Protein C (PC-Gla) for Sepsis Treatment

Wonhwa Lee, Junyoung Seo, Soyoung Kwak, Eun Ji Park, Dong Hee Na, Soyoun Kim, You Mie Lee, In-San Kim, Jong Sup Bae

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

New protein nanocages are designed bearing two functional proteins, γ-carboxyglutamic acid of protein C (PC-Gla) and thrombin receptor agonist peptide (TRAP), and have an anti-septic response. These nanoparticles reduce sepsis-induced organ injury and septic mortality in vivo. Noting that there are currently no medications for severe sepsis, these results show that novel nanoparticles can be used to treat sepsis.

Original language	English
Pages (from-to)	6637-6643
Number of pages	7
Journal	Advanced Materials
Volume	27
Issue number	42
DOIs	https://doi.org/10.1002/adma.201503093
Publication status	Published - 2015 Nov 1

Keywords

ferritin
nanoparticles
PC-gla
sepsis
TRAP

ASJC Scopus subject areas

Materials Science(all)
Mechanics of Materials
Mechanical Engineering

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10.1002/adma.201503093

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abstract = "New protein nanocages are designed bearing two functional proteins, γ-carboxyglutamic acid of protein C (PC-Gla) and thrombin receptor agonist peptide (TRAP), and have an anti-septic response. These nanoparticles reduce sepsis-induced organ injury and septic mortality in vivo. Noting that there are currently no medications for severe sepsis, these results show that novel nanoparticles can be used to treat sepsis.",

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T1 - A Double-Chambered Protein Nanocage Loaded with Thrombin Receptor Agonist Peptide (TRAP) and γ-Carboxyglutamic Acid of Protein C (PC-Gla) for Sepsis Treatment

AU - Lee, Wonhwa

AU - Seo, Junyoung

AU - Kwak, Soyoung

AU - Park, Eun Ji

AU - Na, Dong Hee

AU - Kim, Soyoun

AU - Lee, You Mie

AU - Kim, In-San

AU - Bae, Jong Sup

PY - 2015/11/1

Y1 - 2015/11/1

N2 - New protein nanocages are designed bearing two functional proteins, γ-carboxyglutamic acid of protein C (PC-Gla) and thrombin receptor agonist peptide (TRAP), and have an anti-septic response. These nanoparticles reduce sepsis-induced organ injury and septic mortality in vivo. Noting that there are currently no medications for severe sepsis, these results show that novel nanoparticles can be used to treat sepsis.

AB - New protein nanocages are designed bearing two functional proteins, γ-carboxyglutamic acid of protein C (PC-Gla) and thrombin receptor agonist peptide (TRAP), and have an anti-septic response. These nanoparticles reduce sepsis-induced organ injury and septic mortality in vivo. Noting that there are currently no medications for severe sepsis, these results show that novel nanoparticles can be used to treat sepsis.

KW - ferritin

KW - nanoparticles

KW - PC-gla

KW - sepsis

KW - TRAP

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A Double-Chambered Protein Nanocage Loaded with Thrombin Receptor Agonist Peptide (TRAP) and γ-Carboxyglutamic Acid of Protein C (PC-Gla) for Sepsis Treatment

Abstract

Keywords

ASJC Scopus subject areas

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