A facile synthesis of 2,3-disubstituted pyrrolo[2,3-b]pyridines via palladium-catalyzed heteroannulation with internal alkynes

Sang Sun Park, Joong Kwon Choi, Eul Kgun Yum, Deok Chan Ha

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    116 Citations (Scopus)

    Abstract

    2,3-Disubstituted pyrrolo[2,3-b]pyridines were synthesized by palladium-catalyzed heteroannulation of 2-amino-3-iodopyridine derivatives and internal alkynes with Pd(OAc)2, LiCl, and KOAc in DMF. The 2-trimethylsilyl-3-methylpyrrolo[2,3-b]pyridine was transformed to 2-substituted-3-methylpyrrolo[2,3-b]pyridines.

    Original languageEnglish
    Pages (from-to)627-630
    Number of pages4
    JournalTetrahedron Letters
    Volume39
    Issue number7
    DOIs
    Publication statusPublished - 1998 Feb 12

    ASJC Scopus subject areas

    • Biochemistry
    • Drug Discovery
    • Organic Chemistry

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