A facile synthesis of 2,3-disubstituted pyrrolo[2,3-b]pyridines via palladium-catalyzed heteroannulation with internal alkynes

Sang Sun Park; Joong Kwon Choi; Eul Kgun Yum; Deok Chan Ha

doi:10.1016/S0040-4039(97)10662-1

A facile synthesis of 2,3-disubstituted pyrrolo[2,3-b]pyridines via palladium-catalyzed heteroannulation with internal alkynes

Sang Sun Park, Joong Kwon Choi, Eul Kgun Yum, Deok Chan Ha

College of Science

Research output: Contribution to journal › Article › peer-review

113 Citations (Scopus)

Abstract

2,3-Disubstituted pyrrolo[2,3-b]pyridines were synthesized by palladium-catalyzed heteroannulation of 2-amino-3-iodopyridine derivatives and internal alkynes with Pd(OAc)₂, LiCl, and KOAc in DMF. The 2-trimethylsilyl-3-methylpyrrolo[2,3-b]pyridine was transformed to 2-substituted-3-methylpyrrolo[2,3-b]pyridines.

Original language	English
Pages (from-to)	627-630
Number of pages	4
Journal	Tetrahedron Letters
Volume	39
Issue number	7
DOIs	https://doi.org/10.1016/S0040-4039(97)10662-1
Publication status	Published - 1998 Feb 12

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

Access to Document

10.1016/S0040-4039(97)10662-1

Cite this

@article{ba81c7abce7d4b57a8d0417817061ab1,

title = "A facile synthesis of 2,3-disubstituted pyrrolo[2,3-b]pyridines via palladium-catalyzed heteroannulation with internal alkynes",

abstract = "2,3-Disubstituted pyrrolo[2,3-b]pyridines were synthesized by palladium-catalyzed heteroannulation of 2-amino-3-iodopyridine derivatives and internal alkynes with Pd(OAc)2, LiCl, and KOAc in DMF. The 2-trimethylsilyl-3-methylpyrrolo[2,3-b]pyridine was transformed to 2-substituted-3-methylpyrrolo[2,3-b]pyridines.",

author = "Park, {Sang Sun} and Choi, {Joong Kwon} and Yum, {Eul Kgun} and Ha, {Deok Chan}",

year = "1998",

month = feb,

day = "12",

doi = "10.1016/S0040-4039(97)10662-1",

language = "English",

volume = "39",

pages = "627--630",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Limited",

number = "7",

}

TY - JOUR

T1 - A facile synthesis of 2,3-disubstituted pyrrolo[2,3-b]pyridines via palladium-catalyzed heteroannulation with internal alkynes

AU - Park, Sang Sun

AU - Choi, Joong Kwon

AU - Yum, Eul Kgun

AU - Ha, Deok Chan

PY - 1998/2/12

Y1 - 1998/2/12

N2 - 2,3-Disubstituted pyrrolo[2,3-b]pyridines were synthesized by palladium-catalyzed heteroannulation of 2-amino-3-iodopyridine derivatives and internal alkynes with Pd(OAc)2, LiCl, and KOAc in DMF. The 2-trimethylsilyl-3-methylpyrrolo[2,3-b]pyridine was transformed to 2-substituted-3-methylpyrrolo[2,3-b]pyridines.

AB - 2,3-Disubstituted pyrrolo[2,3-b]pyridines were synthesized by palladium-catalyzed heteroannulation of 2-amino-3-iodopyridine derivatives and internal alkynes with Pd(OAc)2, LiCl, and KOAc in DMF. The 2-trimethylsilyl-3-methylpyrrolo[2,3-b]pyridine was transformed to 2-substituted-3-methylpyrrolo[2,3-b]pyridines.

UR - http://www.scopus.com/inward/record.url?scp=0032510081&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032510081&partnerID=8YFLogxK

U2 - 10.1016/S0040-4039(97)10662-1

DO - 10.1016/S0040-4039(97)10662-1

M3 - Article

AN - SCOPUS:0032510081

SN - 0040-4039

VL - 39

SP - 627

EP - 630

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 7

ER -

A facile synthesis of 2,3-disubstituted pyrrolo[2,3-b]pyridines via palladium-catalyzed heteroannulation with internal alkynes

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this