A facile synthesis of 2,3-disubstituted pyrrolo[2,3-b]pyridines via palladium-catalyzed heteroannulation with internal alkynes

Sang Sun Park; Joong Kwon Choi; Eul Kgun Yum; Deok Chan Ha

doi:10.1016/S0040-4039(97)10662-1

A facile synthesis of 2,3-disubstituted pyrrolo[2,3-b]pyridines via palladium-catalyzed heteroannulation with internal alkynes

Sang Sun Park, Joong Kwon Choi, Eul Kgun Yum, Deok Chan Ha

Research output: Contribution to journal › Article › peer-review

116 Citations (Scopus)

Abstract

2,3-Disubstituted pyrrolo[2,3-b]pyridines were synthesized by palladium-catalyzed heteroannulation of 2-amino-3-iodopyridine derivatives and internal alkynes with Pd(OAc)₂, LiCl, and KOAc in DMF. The 2-trimethylsilyl-3-methylpyrrolo[2,3-b]pyridine was transformed to 2-substituted-3-methylpyrrolo[2,3-b]pyridines.

Original language	English
Pages (from-to)	627-630
Number of pages	4
Journal	Tetrahedron Letters
Volume	39
Issue number	7
DOIs	https://doi.org/10.1016/S0040-4039(97)10662-1
Publication status	Published - 1998 Feb 12

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4039(97)10662-1

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title = "A facile synthesis of 2,3-disubstituted pyrrolo[2,3-b]pyridines via palladium-catalyzed heteroannulation with internal alkynes",

abstract = "2,3-Disubstituted pyrrolo[2,3-b]pyridines were synthesized by palladium-catalyzed heteroannulation of 2-amino-3-iodopyridine derivatives and internal alkynes with Pd(OAc)2, LiCl, and KOAc in DMF. The 2-trimethylsilyl-3-methylpyrrolo[2,3-b]pyridine was transformed to 2-substituted-3-methylpyrrolo[2,3-b]pyridines.",

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T1 - A facile synthesis of 2,3-disubstituted pyrrolo[2,3-b]pyridines via palladium-catalyzed heteroannulation with internal alkynes

AU - Park, Sang Sun

AU - Choi, Joong Kwon

AU - Yum, Eul Kgun

AU - Ha, Deok Chan

PY - 1998/2/12

Y1 - 1998/2/12

N2 - 2,3-Disubstituted pyrrolo[2,3-b]pyridines were synthesized by palladium-catalyzed heteroannulation of 2-amino-3-iodopyridine derivatives and internal alkynes with Pd(OAc)2, LiCl, and KOAc in DMF. The 2-trimethylsilyl-3-methylpyrrolo[2,3-b]pyridine was transformed to 2-substituted-3-methylpyrrolo[2,3-b]pyridines.

AB - 2,3-Disubstituted pyrrolo[2,3-b]pyridines were synthesized by palladium-catalyzed heteroannulation of 2-amino-3-iodopyridine derivatives and internal alkynes with Pd(OAc)2, LiCl, and KOAc in DMF. The 2-trimethylsilyl-3-methylpyrrolo[2,3-b]pyridine was transformed to 2-substituted-3-methylpyrrolo[2,3-b]pyridines.

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U2 - 10.1016/S0040-4039(97)10662-1

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VL - 39

SP - 627

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JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 7

ER -

A facile synthesis of 2,3-disubstituted pyrrolo[2,3-b]pyridines via palladium-catalyzed heteroannulation with internal alkynes

Abstract

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