Abstract
A variety of diazepinone derivatives were prepared from α-amino acids and amino alcohols by a new synthetic methodology based on ring closing metathesis as a key step. The diazepinones were coupled with ribose derivatives to afford novel diazepinone nucleosides. Among them, (4R)-1-ribosyl-4-methyl-3,4-dihydro-1H-1,3-diazepin-2(7H)-one (3) showed a potent inhibitory effect (K i = 145.97 ± 4.87 nM) against human cytidine deaminase.
Original language | English |
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Pages (from-to) | 11443-11445 |
Number of pages | 3 |
Journal | Chemical Communications |
Volume | 48 |
Issue number | 93 |
DOIs | |
Publication status | Published - 2012 Oct 29 |
ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials
- Ceramics and Composites
- Metals and Alloys
- Materials Chemistry
- Surfaces, Coatings and Films
- Chemistry(all)
- Catalysis