TY - JOUR
T1 - A few antibiotics can represent the total hospital antibiotic consumption
AU - Kim, Bongyoung
AU - Hwang, Hyeonjun
AU - Kim, Jieun
AU - Lee, Myoung jae
AU - Pai, Hyunjoo
N1 - Funding Information:
This work was supported by a grant from the Korea Healthcare Technology R&D Project, Nationwide surveillance system of multidrug-resistant pathogens for prevention and control of antimicrobial resistance in Korea (HI12C0756), Ministry of Health and Welfare, Republic of Korea.
Publisher Copyright:
© 2018 The Author(s).
PY - 2018/5/31
Y1 - 2018/5/31
N2 - Background: Appropriate antibiotic use has become an important issue. However, collecting data on the use of all antibiotics in a hospital is difficult without an advanced computerized system and dedicated staff. This paper examines if 1-3 antibiotics can satisfactorily represent the total antibiotic consumption at the hospital level. Methods: We collected antibiotic data from six large university hospitals in Korea for some years between 2004 and 2012. Since the total antibiotics consist of a few chosen representative antibiotics and the rest, we used those chosen antibiotics along with additional variables constructed only with t (time) such as t, t 2 , and t 3 to capture the time trend and whether t belongs to each month or not to capture the monthly variations. The ordinary least squares method was used to explain the total antibiotic amount with these variables, and then the estimated model was employed to predict the use for 2013. To determine which antibiotics were the most representative in tracking general trends in antibiotic use over time, we tried various combinations of antibiotics to find the combination that best minimized the 2013 prediction error. Results: We found that fluoroquinolones and aminoglycosides were the most representative, followed by beta-lactam/beta-lactamase inhibitors and 4th-generation and 3rd-generation cephalosporins. The mean prediction error over 12months in 2013 with these few antibiotics was only 1-3% of the monthly antibiotic consumption amount. Conclusions: The total antibiotic consumption amount at the hospital level can be represented sufficiently by a few antibiotics, such as fluoroquinolones and aminoglycosides, which means that hospitals can save resources by tracing only the usage of those few antibiotics instead of the entire inventory. Since the choice of fluoroquinolones and aminoglycosides is based solely on our Korean data, other hospitals may follow the same modelling methodology to find their own representative antibiotics.
AB - Background: Appropriate antibiotic use has become an important issue. However, collecting data on the use of all antibiotics in a hospital is difficult without an advanced computerized system and dedicated staff. This paper examines if 1-3 antibiotics can satisfactorily represent the total antibiotic consumption at the hospital level. Methods: We collected antibiotic data from six large university hospitals in Korea for some years between 2004 and 2012. Since the total antibiotics consist of a few chosen representative antibiotics and the rest, we used those chosen antibiotics along with additional variables constructed only with t (time) such as t, t 2 , and t 3 to capture the time trend and whether t belongs to each month or not to capture the monthly variations. The ordinary least squares method was used to explain the total antibiotic amount with these variables, and then the estimated model was employed to predict the use for 2013. To determine which antibiotics were the most representative in tracking general trends in antibiotic use over time, we tried various combinations of antibiotics to find the combination that best minimized the 2013 prediction error. Results: We found that fluoroquinolones and aminoglycosides were the most representative, followed by beta-lactam/beta-lactamase inhibitors and 4th-generation and 3rd-generation cephalosporins. The mean prediction error over 12months in 2013 with these few antibiotics was only 1-3% of the monthly antibiotic consumption amount. Conclusions: The total antibiotic consumption amount at the hospital level can be represented sufficiently by a few antibiotics, such as fluoroquinolones and aminoglycosides, which means that hospitals can save resources by tracing only the usage of those few antibiotics instead of the entire inventory. Since the choice of fluoroquinolones and aminoglycosides is based solely on our Korean data, other hospitals may follow the same modelling methodology to find their own representative antibiotics.
KW - Aminoglycoside
KW - Antibiotic consumption
KW - Antimicrobial stewardship
KW - Fluoroquinolone
KW - Statistical model
UR - http://www.scopus.com/inward/record.url?scp=85047918717&partnerID=8YFLogxK
U2 - 10.1186/s12879-018-3132-7
DO - 10.1186/s12879-018-3132-7
M3 - Article
C2 - 29855273
AN - SCOPUS:85047918717
SN - 1471-2334
VL - 18
JO - BMC Infectious Diseases
JF - BMC Infectious Diseases
IS - 1
M1 - 247
ER -
