A fluorescence off-on reporter for real time monitoring of gemcitabine delivery to the cancer cells

Sankarprasad Bhuniya; Min Hee Lee; Hyun Mi Jeon; Ji Hye Han; Jae Hong Lee; Nayoung Park; Sukhendu Maiti; Chulhun Kang; Jong Seung Kim

doi:10.1039/c3cc42653j

A fluorescence off-on reporter for real time monitoring of gemcitabine delivery to the cancer cells

Sankarprasad Bhuniya, Min Hee Lee, Hyun Mi Jeon, Ji Hye Han, Jae Hong Lee, Nayoung Park, Sukhendu Maiti, Chulhun Kang, Jong Seung Kim

Research output: Contribution to journal › Article › peer-review

76 Citations (Scopus)

Abstract

We present the design, synthesis, optical properties and in vitro biological assessments of the theranostic prodrug6 in which a near IR fluorophore is conjugated with a cancer cell-directing biotin unit; further it is linked with the anti-cancer drug gemcitabine via a self-immolative spacer, a disulfide bond. The prodrug 6 s able to monitor drug delivery and cellular imaging.

Original language	English
Pages (from-to)	7141-7143
Number of pages	3
Journal	Chemical Communications
Volume	49
Issue number	64
DOIs	https://doi.org/10.1039/c3cc42653j
Publication status	Published - 2013 Jul 16

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1039/c3cc42653j

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abstract = "We present the design, synthesis, optical properties and in vitro biological assessments of the theranostic prodrug6 in which a near IR fluorophore is conjugated with a cancer cell-directing biotin unit; further it is linked with the anti-cancer drug gemcitabine via a self-immolative spacer, a disulfide bond. The prodrug 6 s able to monitor drug delivery and cellular imaging.",

author = "Sankarprasad Bhuniya and Lee, {Min Hee} and Jeon, {Hyun Mi} and Han, {Ji Hye} and Lee, {Jae Hong} and Nayoung Park and Sukhendu Maiti and Chulhun Kang and Kim, {Jong Seung}",

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AU - Bhuniya, Sankarprasad

AU - Lee, Min Hee

AU - Jeon, Hyun Mi

AU - Han, Ji Hye

AU - Lee, Jae Hong

AU - Park, Nayoung

AU - Maiti, Sukhendu

AU - Kang, Chulhun

AU - Kim, Jong Seung

PY - 2013/7/16

Y1 - 2013/7/16

N2 - We present the design, synthesis, optical properties and in vitro biological assessments of the theranostic prodrug6 in which a near IR fluorophore is conjugated with a cancer cell-directing biotin unit; further it is linked with the anti-cancer drug gemcitabine via a self-immolative spacer, a disulfide bond. The prodrug 6 s able to monitor drug delivery and cellular imaging.

AB - We present the design, synthesis, optical properties and in vitro biological assessments of the theranostic prodrug6 in which a near IR fluorophore is conjugated with a cancer cell-directing biotin unit; further it is linked with the anti-cancer drug gemcitabine via a self-immolative spacer, a disulfide bond. The prodrug 6 s able to monitor drug delivery and cellular imaging.

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A fluorescence off-on reporter for real time monitoring of gemcitabine delivery to the cancer cells

Abstract

ASJC Scopus subject areas

UN SDGs

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