RNA demethylase has recently been known to be associated with cancer development but its selective inhibitors as anti-cancer agents have rarely been investigated to date. Herein, we have developed a fluorescent nanobiosensor which enables efficient quantitative analysis of RNA demethylase ALKBH5 activity and shows a high potential for robust inhibitor screening.
Bibliographical noteFunding Information:
This work was supported by the Basic Science Research Program (2016R1E1A1A01941202), the International S&T Cooperation Program (2014K1B1A1073716), and the Research Centre Program (IBS-R008-D1) of IBS (Institute for Basic Science) through the National Research Foundation of Korea (NRF) and by Lemonex Inc. (LEMONEX-SN201709-3-12, LEMONEX-SN201901-3-30).
This journal is © The Royal Society of Chemistry.
ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials
- Ceramics and Composites
- General Chemistry
- Surfaces, Coatings and Films
- Metals and Alloys
- Materials Chemistry