A fluorescent nanobiosensor for the facile analysis of m6A RNA demethylase activity

Seo Hee Yim, Hyung Jin Cha, Se Jin Park, Yeajee Yim, Jae Sung Woo, Dal Hee Min

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

RNA demethylase has recently been known to be associated with cancer development but its selective inhibitors as anti-cancer agents have rarely been investigated to date. Herein, we have developed a fluorescent nanobiosensor which enables efficient quantitative analysis of RNA demethylase ALKBH5 activity and shows a high potential for robust inhibitor screening.

Original languageEnglish
Pages (from-to)4716-4719
Number of pages4
JournalChemical Communications
Volume56
Issue number34
DOIs
Publication statusPublished - 2020 Apr 30

Bibliographical note

Funding Information:
This work was supported by the Basic Science Research Program (2016R1E1A1A01941202), the International S&T Cooperation Program (2014K1B1A1073716), and the Research Centre Program (IBS-R008-D1) of IBS (Institute for Basic Science) through the National Research Foundation of Korea (NRF) and by Lemonex Inc. (LEMONEX-SN201709-3-12, LEMONEX-SN201901-3-30).

Publisher Copyright:
This journal is © The Royal Society of Chemistry.

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • General Chemistry
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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