A genome-wide association study of seasonal pattern mania identifies NF1A as a possible susceptibility gene for bipolar disorder

Heon Jeong Lee; Hyun Goo Woo; Tiffany A. Greenwood; Daniel F. Kripke; John R. Kelsoe

doi:10.1016/j.jad.2012.07.032

A genome-wide association study of seasonal pattern mania identifies NF1A as a possible susceptibility gene for bipolar disorder

Heon Jeong Lee
, Hyun Goo Woo
, Tiffany A. Greenwood
, Daniel F. Kripke
, John R. Kelsoe^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

40 Citations (Scopus)

Abstract

Objective: The use of subphenotypes may be an effective approach for genetic studies of complex diseases. Manic episodes with a seasonal pattern may distinguish phenotypic subgroups of bipolar subjects that may also differ genetically. Method: We have performed a genome-wide association study using GAIN genotype data from the Bipolar Genome Study (BiGS) and bipolar subjects that were categorized as having either seasonal or non-seasonal patterned manic episodes. Results: A bipolar case-only analysis identified three genomic regions that differed between seasonal and non-seasonal patterned manic episodes of bipolar subjects. The most significant association was for rs41350144, which lies within an intron of NF1A gene on 1p31 (P=3.08×10^-7, OR=2.27). Haplotype construction using flanking three SNPs (rs41453448, rs1125777, and rs12568010) spanning 7549 bp showed a more significant association (P=2.12×10^-7, OR=0.4). Conclusions: These data suggest that genetic variants in the NF1A gene region may predispose to seasonal patterned of mania in bipolar disorder.

Original language	English
Pages (from-to)	200-207
Number of pages	8
Journal	Journal of Affective Disorders
Volume	145
Issue number	2
DOIs	https://doi.org/10.1016/j.jad.2012.07.032
Publication status	Published - 2013 Feb 20

Bibliographical note

Funding Information:
This work was supported by grants from the National Institute of Mental Health (NIMH) and National Human Genome Research Institute (NHGRI) to JRK (MH078151, MH081804, and MH059567 supplement), and by the Genetic Association Information Network (GAIN).

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Bipolar disorder
Genome-wide association
Seasonal pattern

ASJC Scopus subject areas

Clinical Psychology
Psychiatry and Mental health

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10.1016/j.jad.2012.07.032

Cite this

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title = "A genome-wide association study of seasonal pattern mania identifies NF1A as a possible susceptibility gene for bipolar disorder",

abstract = "Objective: The use of subphenotypes may be an effective approach for genetic studies of complex diseases. Manic episodes with a seasonal pattern may distinguish phenotypic subgroups of bipolar subjects that may also differ genetically. Method: We have performed a genome-wide association study using GAIN genotype data from the Bipolar Genome Study (BiGS) and bipolar subjects that were categorized as having either seasonal or non-seasonal patterned manic episodes. Results: A bipolar case-only analysis identified three genomic regions that differed between seasonal and non-seasonal patterned manic episodes of bipolar subjects. The most significant association was for rs41350144, which lies within an intron of NF1A gene on 1p31 (P=3.08×10-7, OR=2.27). Haplotype construction using flanking three SNPs (rs41453448, rs1125777, and rs12568010) spanning 7549 bp showed a more significant association (P=2.12×10-7, OR=0.4). Conclusions: These data suggest that genetic variants in the NF1A gene region may predispose to seasonal patterned of mania in bipolar disorder.",

keywords = "Bipolar disorder, Genome-wide association, Seasonal pattern",

author = "Lee, \{Heon Jeong\} and Woo, \{Hyun Goo\} and Greenwood, \{Tiffany A.\} and Kripke, \{Daniel F.\} and Kelsoe, \{John R.\}",

note = "Funding Information: This work was supported by grants from the National Institute of Mental Health (NIMH) and National Human Genome Research Institute (NHGRI) to JRK (MH078151, MH081804, and MH059567 supplement), and by the Genetic Association Information Network (GAIN). ",

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AU - Greenwood, Tiffany A.

AU - Kripke, Daniel F.

AU - Kelsoe, John R.

N1 - Funding Information: This work was supported by grants from the National Institute of Mental Health (NIMH) and National Human Genome Research Institute (NHGRI) to JRK (MH078151, MH081804, and MH059567 supplement), and by the Genetic Association Information Network (GAIN).

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N2 - Objective: The use of subphenotypes may be an effective approach for genetic studies of complex diseases. Manic episodes with a seasonal pattern may distinguish phenotypic subgroups of bipolar subjects that may also differ genetically. Method: We have performed a genome-wide association study using GAIN genotype data from the Bipolar Genome Study (BiGS) and bipolar subjects that were categorized as having either seasonal or non-seasonal patterned manic episodes. Results: A bipolar case-only analysis identified three genomic regions that differed between seasonal and non-seasonal patterned manic episodes of bipolar subjects. The most significant association was for rs41350144, which lies within an intron of NF1A gene on 1p31 (P=3.08×10-7, OR=2.27). Haplotype construction using flanking three SNPs (rs41453448, rs1125777, and rs12568010) spanning 7549 bp showed a more significant association (P=2.12×10-7, OR=0.4). Conclusions: These data suggest that genetic variants in the NF1A gene region may predispose to seasonal patterned of mania in bipolar disorder.

AB - Objective: The use of subphenotypes may be an effective approach for genetic studies of complex diseases. Manic episodes with a seasonal pattern may distinguish phenotypic subgroups of bipolar subjects that may also differ genetically. Method: We have performed a genome-wide association study using GAIN genotype data from the Bipolar Genome Study (BiGS) and bipolar subjects that were categorized as having either seasonal or non-seasonal patterned manic episodes. Results: A bipolar case-only analysis identified three genomic regions that differed between seasonal and non-seasonal patterned manic episodes of bipolar subjects. The most significant association was for rs41350144, which lies within an intron of NF1A gene on 1p31 (P=3.08×10-7, OR=2.27). Haplotype construction using flanking three SNPs (rs41453448, rs1125777, and rs12568010) spanning 7549 bp showed a more significant association (P=2.12×10-7, OR=0.4). Conclusions: These data suggest that genetic variants in the NF1A gene region may predispose to seasonal patterned of mania in bipolar disorder.

KW - Bipolar disorder

KW - Genome-wide association

KW - Seasonal pattern

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A genome-wide association study of seasonal pattern mania identifies NF1A as a possible susceptibility gene for bipolar disorder

Abstract

Bibliographical note

UN SDGs

Keywords

ASJC Scopus subject areas

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