A hemicyanine complex for the detection of thiol biomolecules by fluorescence

Doan Thanh Nhan; Nguyen Khoa Hien; Hoang Van Duc; Nguyen Thi Ai Nhung; Nguyen Tien Trung; Dang Ung Van; Weon Sup Shin; Jong Seung Kim; Duong Tuan Quang

doi:10.1016/j.dyepig.2016.03.050

A hemicyanine complex for the detection of thiol biomolecules by fluorescence

Doan Thanh Nhan, Nguyen Khoa Hien, Hoang Van Duc, Nguyen Thi Ai Nhung, Nguyen Tien Trung, Dang Ung Van, Weon Sup Shin, Jong Seung Kim, Duong Tuan Quang

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Herein, we report the design and preparation of a benzothiazolium hemicyanine derivative that exhibits red emission at 585 nm. Its complex with Hg²⁺ may be used for selective and sensitive sensing of thiol biomolecules through the reversible visual color and florescence changes they induce in the complex. This complex was used to detect three test thiol biomolecules, and exhibited sensitivity in the order cysteine > glutathione > homocysteine. Furthermore, the complex allowed the detection of cysteine at 0.2 μM, lower than the normal human intracellular cysteine concentration (30-200 μM), and was found to be useable over at least five cycles upon alternate addition of cysteine and Hg²⁺.

Original language	English
Pages (from-to)	301-306
Number of pages	6
Journal	Dyes and Pigments
Volume	131
DOIs	https://doi.org/10.1016/j.dyepig.2016.03.050
Publication status	Published - 2016 Aug

Keywords

Cysteine
Ensemble complex
Fluorescence
Hemicyanine
Thiol biomolecules

ASJC Scopus subject areas

Chemical Engineering(all)
Process Chemistry and Technology

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10.1016/j.dyepig.2016.03.050

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title = "A hemicyanine complex for the detection of thiol biomolecules by fluorescence",

abstract = "Herein, we report the design and preparation of a benzothiazolium hemicyanine derivative that exhibits red emission at 585 nm. Its complex with Hg2+ may be used for selective and sensitive sensing of thiol biomolecules through the reversible visual color and florescence changes they induce in the complex. This complex was used to detect three test thiol biomolecules, and exhibited sensitivity in the order cysteine > glutathione > homocysteine. Furthermore, the complex allowed the detection of cysteine at 0.2 μM, lower than the normal human intracellular cysteine concentration (30-200 μM), and was found to be useable over at least five cycles upon alternate addition of cysteine and Hg2+.",

keywords = "Cysteine, Ensemble complex, Fluorescence, Hemicyanine, Thiol biomolecules",

author = "Nhan, {Doan Thanh} and Hien, {Nguyen Khoa} and {Van Duc}, Hoang and {Ai Nhung}, {Nguyen Thi} and Trung, {Nguyen Tien} and Van, {Dang Ung} and Shin, {Weon Sup} and Kim, {Jong Seung} and Quang, {Duong Tuan}",

note = "Funding Information: This research was funded by the Vietnam National Foundation for Science and Technology Development (NAFOSTED) under grant number 104.04–2014.35 (DTQ) and supported by the CRI project of Korea (No. 2009-0081566 , JSK ). Publisher Copyright: {\textcopyright} 2016 Elsevier Ltd. All rights reserved.",

year = "2016",

month = aug,

doi = "10.1016/j.dyepig.2016.03.050",

language = "English",

volume = "131",

pages = "301--306",

journal = "Dyes and Pigments",

issn = "0143-7208",

publisher = "Elsevier BV",

}

TY - JOUR

T1 - A hemicyanine complex for the detection of thiol biomolecules by fluorescence

AU - Nhan, Doan Thanh

AU - Hien, Nguyen Khoa

AU - Van Duc, Hoang

AU - Ai Nhung, Nguyen Thi

AU - Trung, Nguyen Tien

AU - Van, Dang Ung

AU - Shin, Weon Sup

AU - Kim, Jong Seung

AU - Quang, Duong Tuan

N1 - Funding Information: This research was funded by the Vietnam National Foundation for Science and Technology Development (NAFOSTED) under grant number 104.04–2014.35 (DTQ) and supported by the CRI project of Korea (No. 2009-0081566 , JSK ). Publisher Copyright: © 2016 Elsevier Ltd. All rights reserved.

PY - 2016/8

Y1 - 2016/8

N2 - Herein, we report the design and preparation of a benzothiazolium hemicyanine derivative that exhibits red emission at 585 nm. Its complex with Hg2+ may be used for selective and sensitive sensing of thiol biomolecules through the reversible visual color and florescence changes they induce in the complex. This complex was used to detect three test thiol biomolecules, and exhibited sensitivity in the order cysteine > glutathione > homocysteine. Furthermore, the complex allowed the detection of cysteine at 0.2 μM, lower than the normal human intracellular cysteine concentration (30-200 μM), and was found to be useable over at least five cycles upon alternate addition of cysteine and Hg2+.

AB - Herein, we report the design and preparation of a benzothiazolium hemicyanine derivative that exhibits red emission at 585 nm. Its complex with Hg2+ may be used for selective and sensitive sensing of thiol biomolecules through the reversible visual color and florescence changes they induce in the complex. This complex was used to detect three test thiol biomolecules, and exhibited sensitivity in the order cysteine > glutathione > homocysteine. Furthermore, the complex allowed the detection of cysteine at 0.2 μM, lower than the normal human intracellular cysteine concentration (30-200 μM), and was found to be useable over at least five cycles upon alternate addition of cysteine and Hg2+.

KW - Cysteine

KW - Ensemble complex

KW - Fluorescence

KW - Hemicyanine

KW - Thiol biomolecules

UR - http://www.scopus.com/inward/record.url?scp=84964335075&partnerID=8YFLogxK

U2 - 10.1016/j.dyepig.2016.03.050

DO - 10.1016/j.dyepig.2016.03.050

M3 - Article

AN - SCOPUS:84964335075

SN - 0143-7208

VL - 131

SP - 301

EP - 306

JO - Dyes and Pigments

JF - Dyes and Pigments

ER -

A hemicyanine complex for the detection of thiol biomolecules by fluorescence

Abstract

Keywords

ASJC Scopus subject areas

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