A key 1-β-methylcarbapenem intermediate is synthesized from a highly diastereoselective condensation between the titanium enolate of 2′-hydroxypropiophenone with 4-acetoxy-β-lactam followed by ozonolysis of the resulting ketone to the carboxylic acid.
|Number of pages||4|
|Publication status||Published - 2004 Jan 19|
ASJC Scopus subject areas
- Drug Discovery
- Organic Chemistry