Abstract
A highly sensitive immunoassay was developed by using antibody-conjugated spherical mesoporous silica with immobilized enzymes. The higher ratio of enzyme/antibody than conventional ELISA improved both the sensitivity and dynamic range. Especially, the use of spherical mesoporous silica could achieve a limit of detection (LOD) with a sensitivity that is 20 times more than that of ELISA using amorphous silica.
Original language | English |
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Pages (from-to) | 3546-3548 |
Number of pages | 3 |
Journal | Chemical Communications |
Volume | 50 |
Issue number | 27 |
DOIs | |
Publication status | Published - 2014 Mar 6 |
ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials
- Ceramics and Composites
- Metals and Alloys
- Materials Chemistry
- Surfaces, Coatings and Films
- Chemistry(all)
- Catalysis