TY - JOUR
T1 - A key region in the human parietal cortex for processing proprioceptive hand feedback during reaching movements
AU - Reichenbach, Alexandra
AU - Thielscher, Axel
AU - Peer, Angelika
AU - Bülthoff, Heinrich H.
AU - Bresciani, Jean Pierre
N1 - Funding Information:
This research was supported by a PhD stipend from the Max Planck Society and by the WCU (World Class University) program through the National Research Foundation of Korea funded by the Ministry of Education, Science and Technology ( R31-2008-000-10008-0 ). The authors would like to thank Sonja Cornelsen for help in data acquisition, and Marc Himmelbach for helpful comments on a previous version of the manuscript.
PY - 2014/1/1
Y1 - 2014/1/1
N2 - Seemingly effortless, we adjust our movements to continuously changing environments. After initiation of a goal-directed movement, the motor command is under constant control of sensory feedback loops. The main sensory signals contributing to movement control are vision and proprioception. Recent neuroimaging studies have focused mainly on identifying the parts of the posterior parietal cortex (PPC) that contribute to visually guided movements. We used event-related TMS and force perturbations of the reaching hand to test whether the same sub-regions of the left PPC contribute to the processing of proprioceptive-only and of multi-sensory information about hand position when reaching for a visual target. TMS over two distinct stimulation sites elicited differential effects: TMS applied over the posterior part of the medial intraparietal sulcus (mIPS) compromised reaching accuracy when proprioception was the only sensory information available for correcting the reaching error. When visual feedback of the hand was available, TMS over the anterior intraparietal sulcus (aIPS) prolonged reaching time. Our results show for the first time the causal involvement of the posterior mIPS in processing proprioceptive feedback for online reaching control, and demonstrate that distinct cortical areas process proprioceptive-only and multi-sensory information for fast feedback corrections.
AB - Seemingly effortless, we adjust our movements to continuously changing environments. After initiation of a goal-directed movement, the motor command is under constant control of sensory feedback loops. The main sensory signals contributing to movement control are vision and proprioception. Recent neuroimaging studies have focused mainly on identifying the parts of the posterior parietal cortex (PPC) that contribute to visually guided movements. We used event-related TMS and force perturbations of the reaching hand to test whether the same sub-regions of the left PPC contribute to the processing of proprioceptive-only and of multi-sensory information about hand position when reaching for a visual target. TMS over two distinct stimulation sites elicited differential effects: TMS applied over the posterior part of the medial intraparietal sulcus (mIPS) compromised reaching accuracy when proprioception was the only sensory information available for correcting the reaching error. When visual feedback of the hand was available, TMS over the anterior intraparietal sulcus (aIPS) prolonged reaching time. Our results show for the first time the causal involvement of the posterior mIPS in processing proprioceptive feedback for online reaching control, and demonstrate that distinct cortical areas process proprioceptive-only and multi-sensory information for fast feedback corrections.
KW - Motor control
KW - On-line control
KW - Posterior parietal cortex
KW - Proprioception
KW - Reaching
KW - Transcranial magnetic stimulation
UR - http://www.scopus.com/inward/record.url?scp=84884960533&partnerID=8YFLogxK
U2 - 10.1016/j.neuroimage.2013.09.024
DO - 10.1016/j.neuroimage.2013.09.024
M3 - Article
C2 - 24060316
AN - SCOPUS:84884960533
SN - 1053-8119
VL - 84
SP - 615
EP - 625
JO - NeuroImage
JF - NeuroImage
ER -