TY - JOUR
T1 - A materials-science perspective on tackling COVID-19
AU - Tang, Zhongmin
AU - Kong, Na
AU - Zhang, Xingcai
AU - Liu, Yuan
AU - Hu, Ping
AU - Mou, Shan
AU - Liljeström, Peter
AU - Shi, Jianlin
AU - Tan, Weihong
AU - Kim, Jong Seung
AU - Cao, Yihai
AU - Langer, Robert
AU - Leong, Kam W.
AU - Farokhzad, Omid C.
AU - Tao, Wei
N1 - Funding Information:
This study is supported by the US METAvivor Early Career Investigator Award (No. 2018A020560, W.Tao), Harvard Medical School/Brigham and Women’s Hospital Department of Anaesthesiology Basic Scientist Grant (No. 2420 BPA075, W.Tao) and Center for Nanomedicine Research Fund (No.2019A014810, W.Tao). W.Tao is a recipient of the Khoury Innovation Award (No. 2020A003219) and American Heart Association (AHA) Collaborative Science Award (No. 2018A004190). W.Tao also received a start-up package (for 3 years) from the Department of Anesthesiology, Perioperative and Pain Medicine to establish his independent research laboratory at Harvard Medical School and Brigham and Women’s Hospital. We thank our department for this generous support. We also thank J. Chen from University of California, Los Angeles, for his proofreading and correction before the online publication of this Review.
Publisher Copyright:
© 2020, Springer Nature Limited.
PY - 2020/11/1
Y1 - 2020/11/1
N2 - The ongoing SARS-CoV-2 pandemic highlights the importance of materials science in providing tools and technologies for antiviral research and treatment development. In this Review, we discuss previous efforts in materials science in developing imaging systems and microfluidic devices for the in-depth and real-time investigation of viral structures and transmission, as well as material platforms for the detection of viruses and the delivery of antiviral drugs and vaccines. We highlight the contribution of materials science to the manufacturing of personal protective equipment and to the design of simple, accurate and low-cost virus-detection devices. We then investigate future possibilities of materials science in antiviral research and treatment development, examining the role of materials in antiviral-drug design, including the importance of synthetic material platforms for organoids and organs-on-a-chip, in drug delivery and vaccination, and for the production of medical equipment. Materials-science-based technologies not only contribute to the ongoing SARS-CoV-2 research efforts but can also provide platforms and tools for the understanding, protection, detection and treatment of future viral diseases.
AB - The ongoing SARS-CoV-2 pandemic highlights the importance of materials science in providing tools and technologies for antiviral research and treatment development. In this Review, we discuss previous efforts in materials science in developing imaging systems and microfluidic devices for the in-depth and real-time investigation of viral structures and transmission, as well as material platforms for the detection of viruses and the delivery of antiviral drugs and vaccines. We highlight the contribution of materials science to the manufacturing of personal protective equipment and to the design of simple, accurate and low-cost virus-detection devices. We then investigate future possibilities of materials science in antiviral research and treatment development, examining the role of materials in antiviral-drug design, including the importance of synthetic material platforms for organoids and organs-on-a-chip, in drug delivery and vaccination, and for the production of medical equipment. Materials-science-based technologies not only contribute to the ongoing SARS-CoV-2 research efforts but can also provide platforms and tools for the understanding, protection, detection and treatment of future viral diseases.
UR - http://www.scopus.com/inward/record.url?scp=85092450020&partnerID=8YFLogxK
U2 - 10.1038/s41578-020-00247-y
DO - 10.1038/s41578-020-00247-y
M3 - Review article
AN - SCOPUS:85092450020
SN - 2058-8437
VL - 5
SP - 847
EP - 860
JO - Nature Reviews Materials
JF - Nature Reviews Materials
IS - 11
ER -
