@article{058be929b2e8485990a81bf8df22b7ef,
title = "A method for single-neuron chronic recording from the retina in awake mice",
abstract = "The retina, which processes visual information and sends it to the brain, is an excellent model for studying neural circuitry. It has been probed extensively ex vivo but has been refractory to chronic in vivo electrophysiology. We report a nonsurgical method to achieve chronically stable in vivo recordings from single retinal ganglion cells (RGCs) in awake mice. We developed a noncoaxial intravitreal injection scheme in which injected mesh electronics unrolls inside the eye and conformally coats the highly curved retina without compromising normal eye functions. The method allows 16-channel recordings from multiple types of RGCs with stable responses to visual stimuli for at least 2 weeks, and reveals circadian rhythms in RGC responses over multiple day/night cycles.",
author = "Guosong Hong and Fu, {Tian Ming} and Mu Qiao and Viveros, {Robert D.} and Xiao Yang and Tao Zhou and Lee, {Jung Min} and Park, {Hong Gyu} and Sanes, {Joshua R.} and Lieber, {Charles M.}",
note = "Funding Information: We thank J. E. Dowling for helpful discussions, M. Meister for useful suggestions, and J. Huang for help with recording instrumentation. Supported by Air Force Office of Scientific Research grant FA9550-14-1-0136, Harvard University Physical Sciences and Engineering Accelerator award, and a NIH Director{\textquoteright}s Pioneer Award 1DP1EB025835-01 (C.M.L.); American Heart Association Postdoctoral Fellowship 16POST27250219 and NIH Pathway to Independence Award from NIA 1K99AG056636-01 (G.H.); a NIH R37 grant from NINDS NS029169 (M.Q. and J.R.S.); and the Harvard University Center for Nanoscale Systems supported by NSF. Publisher Copyright: {\textcopyright} 2017 The Authors",
year = "2018",
month = jun,
day = "29",
doi = "10.1126/science.aas9160",
language = "English",
volume = "360",
pages = "1447--1451",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "6396",
}