A microfluidic device with integrated impedance detection for λ-DNA

Myung Il Park; Jonging Hong; Dae Sung Yoon; Chong Ook Park; Geunbae Im

doi:10.1557/proc-773-n6.5

A microfluidic device with integrated impedance detection for λ-DNA

Myung Il Park, Jonging Hong, Dae Sung Yoon, Chong Ook Park, Geunbae Im

Research output: Contribution to journal › Conference article › peer-review

3 Citations (Scopus)

Abstract

The large optical detection systems that are typically utilized at present may not be able to reach their full potential as portable analysis tools. Accurate, early, and fast diagnosis for many diseases requires the direct detection of biomolecules such as DNA, proteins, and cells. In this research, a glass microchip with integrated microelectrodes has been fabricated, and the performance of electrochemical impedance detection was investigated for the biomolecules. We have used label-free λ-DNA as a sample biomolecule. By changing the distance between microelectrodes, the significant difference between DW and the TE buffer solution is obtained from the impedance-frequency measurements. In addition, the comparison for the impedance magnitude of DW, the TE buffer, and λ-DNA at the same distance was analyzed.

Original language	English
Pages (from-to)	149-154
Number of pages	6
Journal	Materials Research Society Symposium - Proceedings
Volume	773
DOIs	https://doi.org/10.1557/proc-773-n6.5
Publication status	Published - 2003
Externally published	Yes
Event	Biomicroelectromechanical Systems (BioMEMS) - San Francisco, CA, United States Duration: 2003 Apr 22 → 2003 Apr 25

ASJC Scopus subject areas

Materials Science(all)
Condensed Matter Physics
Mechanics of Materials
Mechanical Engineering

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title = "A microfluidic device with integrated impedance detection for λ-DNA",

abstract = "The large optical detection systems that are typically utilized at present may not be able to reach their full potential as portable analysis tools. Accurate, early, and fast diagnosis for many diseases requires the direct detection of biomolecules such as DNA, proteins, and cells. In this research, a glass microchip with integrated microelectrodes has been fabricated, and the performance of electrochemical impedance detection was investigated for the biomolecules. We have used label-free λ-DNA as a sample biomolecule. By changing the distance between microelectrodes, the significant difference between DW and the TE buffer solution is obtained from the impedance-frequency measurements. In addition, the comparison for the impedance magnitude of DW, the TE buffer, and λ-DNA at the same distance was analyzed.",

author = "Park, {Myung Il} and Jonging Hong and Yoon, {Dae Sung} and Park, {Chong Ook} and Geunbae Im",

year = "2003",

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volume = "773",

pages = "149--154",

journal = "Materials Research Society Symposium Proceedings",

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note = "Biomicroelectromechanical Systems (BioMEMS) ; Conference date: 22-04-2003 Through 25-04-2003",

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T1 - A microfluidic device with integrated impedance detection for λ-DNA

AU - Park, Myung Il

AU - Hong, Jonging

AU - Yoon, Dae Sung

AU - Park, Chong Ook

AU - Im, Geunbae

PY - 2003

Y1 - 2003

N2 - The large optical detection systems that are typically utilized at present may not be able to reach their full potential as portable analysis tools. Accurate, early, and fast diagnosis for many diseases requires the direct detection of biomolecules such as DNA, proteins, and cells. In this research, a glass microchip with integrated microelectrodes has been fabricated, and the performance of electrochemical impedance detection was investigated for the biomolecules. We have used label-free λ-DNA as a sample biomolecule. By changing the distance between microelectrodes, the significant difference between DW and the TE buffer solution is obtained from the impedance-frequency measurements. In addition, the comparison for the impedance magnitude of DW, the TE buffer, and λ-DNA at the same distance was analyzed.

AB - The large optical detection systems that are typically utilized at present may not be able to reach their full potential as portable analysis tools. Accurate, early, and fast diagnosis for many diseases requires the direct detection of biomolecules such as DNA, proteins, and cells. In this research, a glass microchip with integrated microelectrodes has been fabricated, and the performance of electrochemical impedance detection was investigated for the biomolecules. We have used label-free λ-DNA as a sample biomolecule. By changing the distance between microelectrodes, the significant difference between DW and the TE buffer solution is obtained from the impedance-frequency measurements. In addition, the comparison for the impedance magnitude of DW, the TE buffer, and λ-DNA at the same distance was analyzed.

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DO - 10.1557/proc-773-n6.5

M3 - Conference article

AN - SCOPUS:1542274285

SN - 0272-9172

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JO - Materials Research Society Symposium Proceedings

JF - Materials Research Society Symposium Proceedings

T2 - Biomicroelectromechanical Systems (BioMEMS)

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ER -

A microfluidic device with integrated impedance detection for λ-DNA

Abstract

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