A multisized piezoelectric microcantilever biosensor array for the quantitative analysis of mass and surface stress

Sanghun Shin; Jun Pyo Kim; Sang Jun Sim; Jaichan Lee

doi:10.1063/1.2977869

A multisized piezoelectric microcantilever biosensor array for the quantitative analysis of mass and surface stress

Sanghun Shin, Jun Pyo Kim, Sang Jun Sim, Jaichan Lee

Research output: Contribution to journal › Article › peer-review

46 Citations (Scopus)

Abstract

A multisized piezoelectric microcantilever biosensor array with scaling down in two dimensions is presented as a multifunctional resonant cantilever-based sensor platform. The multisized microcantilever array allowed simultaneous sensing of the surface stress as well as mass. The adsorption-induced surface stress and resulting spring constant change were analyzed in the multisized microcantilever array, and a mass sensitivity in the femtogram regime was demonstrated. The array sensor was used to immobilize human IgG on its cantilever surface, suggesting that the dynamic and simultaneous analysis of both adsorption-induced mass and the surface stress is feasible.

Original language	English
Article number	102902
Journal	Applied Physics Letters
Volume	93
Issue number	10
DOIs	https://doi.org/10.1063/1.2977869
Publication status	Published - 2008
Externally published	Yes

Bibliographical note

Funding Information:
This study was supported by the Korea Science and Engineering Foundation (KOSEF) through the National Research Lab (NRL) program (M10400000364).

ASJC Scopus subject areas

Physics and Astronomy (miscellaneous)

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10.1063/1.2977869

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title = "A multisized piezoelectric microcantilever biosensor array for the quantitative analysis of mass and surface stress",

abstract = "A multisized piezoelectric microcantilever biosensor array with scaling down in two dimensions is presented as a multifunctional resonant cantilever-based sensor platform. The multisized microcantilever array allowed simultaneous sensing of the surface stress as well as mass. The adsorption-induced surface stress and resulting spring constant change were analyzed in the multisized microcantilever array, and a mass sensitivity in the femtogram regime was demonstrated. The array sensor was used to immobilize human IgG on its cantilever surface, suggesting that the dynamic and simultaneous analysis of both adsorption-induced mass and the surface stress is feasible.",

author = "Sanghun Shin and Kim, {Jun Pyo} and Sim, {Sang Jun} and Jaichan Lee",

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AU - Shin, Sanghun

AU - Kim, Jun Pyo

AU - Sim, Sang Jun

AU - Lee, Jaichan

N1 - Funding Information: This study was supported by the Korea Science and Engineering Foundation (KOSEF) through the National Research Lab (NRL) program (M10400000364).

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AB - A multisized piezoelectric microcantilever biosensor array with scaling down in two dimensions is presented as a multifunctional resonant cantilever-based sensor platform. The multisized microcantilever array allowed simultaneous sensing of the surface stress as well as mass. The adsorption-induced surface stress and resulting spring constant change were analyzed in the multisized microcantilever array, and a mass sensitivity in the femtogram regime was demonstrated. The array sensor was used to immobilize human IgG on its cantilever surface, suggesting that the dynamic and simultaneous analysis of both adsorption-induced mass and the surface stress is feasible.

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A multisized piezoelectric microcantilever biosensor array for the quantitative analysis of mass and surface stress

Abstract

Bibliographical note

ASJC Scopus subject areas

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