A new homogeneity index based on statistical analysis of the dose-volume histogram

Myonggeun Yoon, Sung Yong Park, Dongho Shin, Se Byeong Lee, Hong Ryull Pyo, Dae Yong Kim, Kwan Ho Cho

Research output: Contribution to journalArticlepeer-review

99 Citations (Scopus)


The goal of the present study was to develop a new dose-volume histogram (DVH)- based homogeneity index for effectively evaluating the dose homogeneity of intensity-modulated radiotherapy plans. The new index, called the sigma-index ("S-index") is defined as the standard deviation of the normalized differential DVH curve. In a study of 16 patients with brain tumors at our institution, the S-index was found to vary from 0.80 to 3.15. Our results showed that the S-index provides a more reliable and accurate measure of dose homogeneity than that given by conventional methods. A guideline for evaluating the dose homogeneity of treatment plans based on the S-index and its relation to equivalent uniform dose is discussed.

Original languageEnglish
Pages (from-to)9-17
Number of pages9
JournalJournal of Applied Clinical Medical Physics
Issue number2
Publication statusPublished - 2007
Externally publishedYes


  • Dose-volume histogram
  • Equivalent uniform dose
  • Homogeneity index
  • Intensity-modulated radiotherapy

ASJC Scopus subject areas

  • Radiation
  • Instrumentation
  • Radiology Nuclear Medicine and imaging


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