A new MEMS neural probe system integrated with push-pull microfluidic channels and biosensors for real-time monitoring of neurochemicals

Uikyu Chae; Hyoguen Shin; Hyunjoo Jenny Lee; Jungpyo Lee; Nakwon Choi; Yi Jae Lee; Soo Hyun Lee; Jiwan Woo; Yakdol Cho; Eui Sung Yoon; Hyun Yong Yu; Il Joo Cho

doi:10.1109/MEMSYS.2016.7421627

A new MEMS neural probe system integrated with push-pull microfluidic channels and biosensors for real-time monitoring of neurochemicals

Uikyu Chae, Hyoguen Shin, Hyunjoo Jenny Lee, Jungpyo Lee, Nakwon Choi, Yi Jae Lee, Soo Hyun Lee, Jiwan Woo, Yakdol Cho, Eui Sung Yoon, Hyun Yong Yu, Il Joo Cho

School of Electrical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

2 Citations (Scopus)

Abstract

We present a new MEMS neural probe integrated with two microfluidic channels, a mixer, and biosensors for real-time monitoring of neurochemicals and neural activities. The microfluidic channels for push-pull operation of fluids enable infusion of drugs and extraction of brain fluid at the same time. Also, we can simultaneously monitor neural activities modulated by the infused drug. The real-time monitoring of neurochemicals using the monolithically integrated sensors is a new concept we propose which is enabled through the MEMS technology. The proposed system will provide an important new set of information for brain disease investigation and functional brain-mapping.

Original language	English
Title of host publication	MEMS 2016 - 29th IEEE International Conference on Micro Electro Mechanical Systems
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	329-332
Number of pages	4
ISBN (Electronic)	9781509019731
DOIs	https://doi.org/10.1109/MEMSYS.2016.7421627
Publication status	Published - 2016 Feb 26
Event	29th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2016 - Shanghai, China Duration: 2016 Jan 24 → 2016 Jan 28

Publication series

Name	Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
Volume	2016-February
ISSN (Print)	1084-6999

Other

Other	29th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2016
Country/Territory	China
City	Shanghai
Period	16/1/24 → 16/1/28

Bibliographical note

Publisher Copyright:
© 2016 IEEE.

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Mechanical Engineering
Electrical and Electronic Engineering

Access to Document

10.1109/MEMSYS.2016.7421627

Cite this

Chae, U., Shin, H., Lee, H. J., Lee, J., Choi, N., Lee, Y. J., Lee, S. H., Woo, J., Cho, Y., Yoon, E. S., Yu, H. Y., & Cho, I. J. (2016). A new MEMS neural probe system integrated with push-pull microfluidic channels and biosensors for real-time monitoring of neurochemicals. In MEMS 2016 - 29th IEEE International Conference on Micro Electro Mechanical Systems (pp. 329-332). Article 7421627 (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS); Vol. 2016-February). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/MEMSYS.2016.7421627

A new MEMS neural probe system integrated with push-pull microfluidic channels and biosensors for real-time monitoring of neurochemicals. / Chae, Uikyu; Shin, Hyoguen; Lee, Hyunjoo Jenny et al.
MEMS 2016 - 29th IEEE International Conference on Micro Electro Mechanical Systems. Institute of Electrical and Electronics Engineers Inc., 2016. p. 329-332 7421627 (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS); Vol. 2016-February).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Chae, U, Shin, H, Lee, HJ, Lee, J, Choi, N, Lee, YJ, Lee, SH, Woo, J, Cho, Y, Yoon, ES, Yu, HY & Cho, IJ 2016, A new MEMS neural probe system integrated with push-pull microfluidic channels and biosensors for real-time monitoring of neurochemicals. in MEMS 2016 - 29th IEEE International Conference on Micro Electro Mechanical Systems., 7421627, Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS), vol. 2016-February, Institute of Electrical and Electronics Engineers Inc., pp. 329-332, 29th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2016, Shanghai, China, 16/1/24. https://doi.org/10.1109/MEMSYS.2016.7421627

Chae U, Shin H, Lee HJ, Lee J, Choi N, Lee YJ et al. A new MEMS neural probe system integrated with push-pull microfluidic channels and biosensors for real-time monitoring of neurochemicals. In MEMS 2016 - 29th IEEE International Conference on Micro Electro Mechanical Systems. Institute of Electrical and Electronics Engineers Inc. 2016. p. 329-332. 7421627. (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)). doi: 10.1109/MEMSYS.2016.7421627

Chae, Uikyu ; Shin, Hyoguen ; Lee, Hyunjoo Jenny et al. / A new MEMS neural probe system integrated with push-pull microfluidic channels and biosensors for real-time monitoring of neurochemicals. MEMS 2016 - 29th IEEE International Conference on Micro Electro Mechanical Systems. Institute of Electrical and Electronics Engineers Inc., 2016. pp. 329-332 (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)).

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abstract = "We present a new MEMS neural probe integrated with two microfluidic channels, a mixer, and biosensors for real-time monitoring of neurochemicals and neural activities. The microfluidic channels for push-pull operation of fluids enable infusion of drugs and extraction of brain fluid at the same time. Also, we can simultaneously monitor neural activities modulated by the infused drug. The real-time monitoring of neurochemicals using the monolithically integrated sensors is a new concept we propose which is enabled through the MEMS technology. The proposed system will provide an important new set of information for brain disease investigation and functional brain-mapping.",

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A new MEMS neural probe system integrated with push-pull microfluidic channels and biosensors for real-time monitoring of neurochemicals

Abstract

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