A new VHR dual-specificity protein tyrosine phosphatase inhibitor from Dendrobium moniliforme

Eun Young Bae; Hyuncheol Oh; Won Keun Oh; Min Soo Kim; Beom Seok Kim; Bo Yeon Kim; Cheon Bae Sohn; Hiroyuki Osada; Jong Seog Ahn

doi:10.1055/s-2004-827238

A new VHR dual-specificity protein tyrosine phosphatase inhibitor from Dendrobium moniliforme

Eun Young Bae, Hyuncheol Oh, Won Keun Oh, Min Soo Kim, Beom Seok Kim, Bo Yeon Kim, Cheon Bae Sohn, Hiroyuki Osada, Jong Seog Ahn

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

Bioassay-guided fractionation of the EtOAc-soluble extract of Dendrobium moniliforme afforded a new phenanthraquinone-type metabolite, 7-hydroxy-5,6-dimethoxy-1,4-phenanthrenequinone (1), along with the previously reported 5-hydroxy-3,7-dimethoxy-1,4-phenanthrenequinone (2). The structures of the compounds were identified mainly on the basis of MS and NMR data. Compound 1 inhibited VHR dual-specificity protein tyrosine phosphatase (DS-PTPase) activity in a dose-dependent manner, displaying an IC₅₀ value of 3.0 ± 0.2 μM.

Original language	English
Pages (from-to)	869-870
Number of pages	2
Journal	Planta Medica
Volume	70
Issue number	9
DOIs	https://doi.org/10.1055/s-2004-827238
Publication status	Published - 2004 Sept
Externally published	Yes

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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title = "A new VHR dual-specificity protein tyrosine phosphatase inhibitor from Dendrobium moniliforme",

abstract = "Bioassay-guided fractionation of the EtOAc-soluble extract of Dendrobium moniliforme afforded a new phenanthraquinone-type metabolite, 7-hydroxy-5,6-dimethoxy-1,4-phenanthrenequinone (1), along with the previously reported 5-hydroxy-3,7-dimethoxy-1,4-phenanthrenequinone (2). The structures of the compounds were identified mainly on the basis of MS and NMR data. Compound 1 inhibited VHR dual-specificity protein tyrosine phosphatase (DS-PTPase) activity in a dose-dependent manner, displaying an IC50 value of 3.0 ± 0.2 μM.",

author = "Bae, {Eun Young} and Hyuncheol Oh and Oh, {Won Keun} and Kim, {Min Soo} and Kim, {Beom Seok} and Kim, {Bo Yeon} and Sohn, {Cheon Bae} and Hiroyuki Osada and Ahn, {Jong Seog}",

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doi = "10.1055/s-2004-827238",

language = "English",

volume = "70",

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T1 - A new VHR dual-specificity protein tyrosine phosphatase inhibitor from Dendrobium moniliforme

AU - Bae, Eun Young

AU - Oh, Hyuncheol

AU - Oh, Won Keun

AU - Kim, Min Soo

AU - Kim, Beom Seok

AU - Kim, Bo Yeon

AU - Sohn, Cheon Bae

AU - Osada, Hiroyuki

AU - Ahn, Jong Seog

PY - 2004/9

Y1 - 2004/9

N2 - Bioassay-guided fractionation of the EtOAc-soluble extract of Dendrobium moniliforme afforded a new phenanthraquinone-type metabolite, 7-hydroxy-5,6-dimethoxy-1,4-phenanthrenequinone (1), along with the previously reported 5-hydroxy-3,7-dimethoxy-1,4-phenanthrenequinone (2). The structures of the compounds were identified mainly on the basis of MS and NMR data. Compound 1 inhibited VHR dual-specificity protein tyrosine phosphatase (DS-PTPase) activity in a dose-dependent manner, displaying an IC50 value of 3.0 ± 0.2 μM.

AB - Bioassay-guided fractionation of the EtOAc-soluble extract of Dendrobium moniliforme afforded a new phenanthraquinone-type metabolite, 7-hydroxy-5,6-dimethoxy-1,4-phenanthrenequinone (1), along with the previously reported 5-hydroxy-3,7-dimethoxy-1,4-phenanthrenequinone (2). The structures of the compounds were identified mainly on the basis of MS and NMR data. Compound 1 inhibited VHR dual-specificity protein tyrosine phosphatase (DS-PTPase) activity in a dose-dependent manner, displaying an IC50 value of 3.0 ± 0.2 μM.

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JO - Planta Medica

JF - Planta Medica

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A new VHR dual-specificity protein tyrosine phosphatase inhibitor from Dendrobium moniliforme

Abstract

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