Abstract
In this article, we explore a new fabrication process for a flexible, all polymer, active fluidic delivery system, incorporating a fusion of laser micromachining and microfabrication techniques as well as rapid prototyping technology. Here, we show selective fluidic delivery from isolated microchannels through an electrochemically driven pumping reaction, demonstrate the dispensing of dose volumes up to 5.5 μl, and evaluate the device's performance in terms of its delivery speed and ejection efficiency. Finally, we move this work toward an implantable microfluidic drug delivery device by investigating the device's biocompatibility through a statistical approach that overviews the viability of bovine aortic endothelial cells on polyimide and silicon substrates.
Original language | English |
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Pages (from-to) | 785-791 |
Number of pages | 7 |
Journal | Microfluidics and Nanofluidics |
Volume | 10 |
Issue number | 4 |
DOIs | |
Publication status | Published - 2011 Apr |
Externally published | Yes |
Keywords
- Electrochemistry
- Implantable drug delivery
- Microfluidics Polyimide
- Rapid prototyping
ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials
- Condensed Matter Physics
- Materials Chemistry