Abstract
The majority of endogenous reactive oxygen species (ROS) are produced in the mitochondrial respiratory chain. An imbalance in ROS production alters the intracellular redox homeostasis, triggers DNA damage, and contributes to cancer development and progression. This study identified a novel protein, reactive oxygen species modulator 1 (Romo1), which is localized in the mitochondria. Romo1 was found to increase the level of ROS in the cells. Increased Romo1 expression was observed in various cancer cell lines. This suggests that the increased Romo1 expression during cancer progression may cause persistent oxidative stress to tumor cells, which can increase their malignancy.
Original language | English |
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Pages (from-to) | 649-655 |
Number of pages | 7 |
Journal | Biochemical and biophysical research communications |
Volume | 347 |
Issue number | 3 |
DOIs | |
Publication status | Published - 2006 Sept 1 |
Bibliographical note
Funding Information:This study was supported by a Grant from the Molecular and Cellular BioDiscovery Research Program (M1-0311-00-0035) of the Ministry of Science and Technology of Korea, by a Grant (R11-2005-017-01001-0) of the Research Center for Woman’s Diseases of the KOSEF, and by a Grant (R01-2006-000-10113-0) from the Basic Research Program of the Korea Science and Engineering Foundation.
Keywords
- Mitochondria
- Reactive oxygen species
- Romo1
ASJC Scopus subject areas
- Biophysics
- Biochemistry
- Molecular Biology
- Cell Biology