A novel protein, Romo1, induces ROS production in the mitochondria

Young Min Chung; Jun Suk Kim; Young Do Yoo

doi:10.1016/j.bbrc.2006.06.140

A novel protein, Romo1, induces ROS production in the mitochondria

Young Min Chung
, Jun Suk Kim
, Young Do Yoo^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

120 Citations (Scopus)

Abstract

The majority of endogenous reactive oxygen species (ROS) are produced in the mitochondrial respiratory chain. An imbalance in ROS production alters the intracellular redox homeostasis, triggers DNA damage, and contributes to cancer development and progression. This study identified a novel protein, reactive oxygen species modulator 1 (Romo1), which is localized in the mitochondria. Romo1 was found to increase the level of ROS in the cells. Increased Romo1 expression was observed in various cancer cell lines. This suggests that the increased Romo1 expression during cancer progression may cause persistent oxidative stress to tumor cells, which can increase their malignancy.

Original language	English
Pages (from-to)	649-655
Number of pages	7
Journal	Biochemical and biophysical research communications
Volume	347
Issue number	3
DOIs	https://doi.org/10.1016/j.bbrc.2006.06.140
Publication status	Published - 2006 Sept 1

Bibliographical note

Funding Information:
This study was supported by a Grant from the Molecular and Cellular BioDiscovery Research Program (M1-0311-00-0035) of the Ministry of Science and Technology of Korea, by a Grant (R11-2005-017-01001-0) of the Research Center for Woman’s Diseases of the KOSEF, and by a Grant (R01-2006-000-10113-0) from the Basic Research Program of the Korea Science and Engineering Foundation.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Mitochondria
Reactive oxygen species
Romo1

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1016/j.bbrc.2006.06.140

Cite this

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title = "A novel protein, Romo1, induces ROS production in the mitochondria",

abstract = "The majority of endogenous reactive oxygen species (ROS) are produced in the mitochondrial respiratory chain. An imbalance in ROS production alters the intracellular redox homeostasis, triggers DNA damage, and contributes to cancer development and progression. This study identified a novel protein, reactive oxygen species modulator 1 (Romo1), which is localized in the mitochondria. Romo1 was found to increase the level of ROS in the cells. Increased Romo1 expression was observed in various cancer cell lines. This suggests that the increased Romo1 expression during cancer progression may cause persistent oxidative stress to tumor cells, which can increase their malignancy.",

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doi = "10.1016/j.bbrc.2006.06.140",

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AU - Chung, Young Min

AU - Kim, Jun Suk

AU - Yoo, Young Do

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PY - 2006/9/1

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N2 - The majority of endogenous reactive oxygen species (ROS) are produced in the mitochondrial respiratory chain. An imbalance in ROS production alters the intracellular redox homeostasis, triggers DNA damage, and contributes to cancer development and progression. This study identified a novel protein, reactive oxygen species modulator 1 (Romo1), which is localized in the mitochondria. Romo1 was found to increase the level of ROS in the cells. Increased Romo1 expression was observed in various cancer cell lines. This suggests that the increased Romo1 expression during cancer progression may cause persistent oxidative stress to tumor cells, which can increase their malignancy.

AB - The majority of endogenous reactive oxygen species (ROS) are produced in the mitochondrial respiratory chain. An imbalance in ROS production alters the intracellular redox homeostasis, triggers DNA damage, and contributes to cancer development and progression. This study identified a novel protein, reactive oxygen species modulator 1 (Romo1), which is localized in the mitochondria. Romo1 was found to increase the level of ROS in the cells. Increased Romo1 expression was observed in various cancer cell lines. This suggests that the increased Romo1 expression during cancer progression may cause persistent oxidative stress to tumor cells, which can increase their malignancy.

KW - Mitochondria

KW - Reactive oxygen species

KW - Romo1

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U2 - 10.1016/j.bbrc.2006.06.140

DO - 10.1016/j.bbrc.2006.06.140

M3 - Article

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JO - Biochemical and biophysical research communications

JF - Biochemical and biophysical research communications

IS - 3

ER -

A novel protein, Romo1, induces ROS production in the mitochondria

Abstract

Bibliographical note

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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