A peptide from corn gluten hydrolysate that is inhibitory toward angiotensin I converting enzyme

H. J. Suh; J. H. Whang; H. Lee

doi:10.1023/A:1005688627350

A peptide from corn gluten hydrolysate that is inhibitory toward angiotensin I converting enzyme

H. J. Suh, J. H. Whang, H. Lee

School of Biosystem and Biomedical Science

Research output: Contribution to journal › Article › peer-review

47 Citations (Scopus)

Abstract

A peptide (F₄) that inhibits angiotensin I converting enzyme (ACE) was isolated from corn gluten hydrolysate prepared with Pescalase, a serine protease from Bacillus licheniformis. The N-terminal amino acid sequence of F₄ was Pro-Ser-Gly-Gln-Tyr-Tyr, having the IC₅₀ value of 0.1 mM. The peptide (F₄), at 30 mg kg^-1 body weight of rat, antagonized the rat's pressor response to angiotensin I.

Original language	English
Pages (from-to)	1055-1058
Number of pages	4
Journal	Biotechnology letters
Volume	21
Issue number	12
DOIs	https://doi.org/10.1023/A:1005688627350
Publication status	Published - 1999

Keywords

Angiotensin converting enzyme
Corn gluten
Peptide inhibitor
Pescalase
Protease

ASJC Scopus subject areas

Biotechnology
Bioengineering
Applied Microbiology and Biotechnology

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10.1023/A:1005688627350

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abstract = "A peptide (F4) that inhibits angiotensin I converting enzyme (ACE) was isolated from corn gluten hydrolysate prepared with Pescalase, a serine protease from Bacillus licheniformis. The N-terminal amino acid sequence of F4 was Pro-Ser-Gly-Gln-Tyr-Tyr, having the IC50 value of 0.1 mM. The peptide (F4), at 30 mg kg-1 body weight of rat, antagonized the rat's pressor response to angiotensin I.",

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author = "Suh, {H. J.} and Whang, {J. H.} and H. Lee",

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AU - Whang, J. H.

AU - Lee, H.

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AB - A peptide (F4) that inhibits angiotensin I converting enzyme (ACE) was isolated from corn gluten hydrolysate prepared with Pescalase, a serine protease from Bacillus licheniformis. The N-terminal amino acid sequence of F4 was Pro-Ser-Gly-Gln-Tyr-Tyr, having the IC50 value of 0.1 mM. The peptide (F4), at 30 mg kg-1 body weight of rat, antagonized the rat's pressor response to angiotensin I.

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KW - Corn gluten

KW - Peptide inhibitor

KW - Pescalase

KW - Protease

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DO - 10.1023/A:1005688627350

M3 - Article

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ER -

A peptide from corn gluten hydrolysate that is inhibitory toward angiotensin I converting enzyme

Abstract

Keywords

ASJC Scopus subject areas

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