A peptide from corn gluten hydrolysate that is inhibitory toward angiotensin I converting enzyme

H. J. Suh, J. H. Whang, H. Lee

    Research output: Contribution to journalArticlepeer-review

    54 Citations (Scopus)

    Abstract

    A peptide (F4) that inhibits angiotensin I converting enzyme (ACE) was isolated from corn gluten hydrolysate prepared with Pescalase, a serine protease from Bacillus licheniformis. The N-terminal amino acid sequence of F4 was Pro-Ser-Gly-Gln-Tyr-Tyr, having the IC50 value of 0.1 mM. The peptide (F4), at 30 mg kg-1 body weight of rat, antagonized the rat's pressor response to angiotensin I.

    Original languageEnglish
    Pages (from-to)1055-1058
    Number of pages4
    JournalBiotechnology letters
    Volume21
    Issue number12
    DOIs
    Publication statusPublished - 1999

    Keywords

    • Angiotensin converting enzyme
    • Corn gluten
    • Peptide inhibitor
    • Pescalase
    • Protease

    ASJC Scopus subject areas

    • Biotechnology
    • Bioengineering
    • Applied Microbiology and Biotechnology

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