A peptide from corn gluten hydrolysate that is inhibitory toward angiotensin I converting enzyme

H. J. Suh; J. H. Whang; H. Lee

doi:10.1023/A:1005688627350

A peptide from corn gluten hydrolysate that is inhibitory toward angiotensin I converting enzyme

H. J. Suh^*
, J. H. Whang
, H. Lee

^*Corresponding author for this work

School of Biosystem and Biomedical Science

Research output: Contribution to journal › Article › peer-review

54 Citations (Scopus)

Abstract

A peptide (F₄) that inhibits angiotensin I converting enzyme (ACE) was isolated from corn gluten hydrolysate prepared with Pescalase, a serine protease from Bacillus licheniformis. The N-terminal amino acid sequence of F₄ was Pro-Ser-Gly-Gln-Tyr-Tyr, having the IC₅₀ value of 0.1 mM. The peptide (F₄), at 30 mg kg^-1 body weight of rat, antagonized the rat's pressor response to angiotensin I.

Original language	English
Pages (from-to)	1055-1058
Number of pages	4
Journal	Biotechnology letters
Volume	21
Issue number	12
DOIs	https://doi.org/10.1023/A:1005688627350
Publication status	Published - 1999

Keywords

Angiotensin converting enzyme
Corn gluten
Peptide inhibitor
Pescalase
Protease

ASJC Scopus subject areas

Biotechnology
Bioengineering
Applied Microbiology and Biotechnology

Access to Document

10.1023/A:1005688627350

Cite this

@article{960538d321874c279cade23a29003f97,

title = "A peptide from corn gluten hydrolysate that is inhibitory toward angiotensin I converting enzyme",

abstract = "A peptide (F4) that inhibits angiotensin I converting enzyme (ACE) was isolated from corn gluten hydrolysate prepared with Pescalase, a serine protease from Bacillus licheniformis. The N-terminal amino acid sequence of F4 was Pro-Ser-Gly-Gln-Tyr-Tyr, having the IC50 value of 0.1 mM. The peptide (F4), at 30 mg kg-1 body weight of rat, antagonized the rat's pressor response to angiotensin I.",

keywords = "Angiotensin converting enzyme, Corn gluten, Peptide inhibitor, Pescalase, Protease",

author = "Suh, \{H. J.\} and Whang, \{J. H.\} and H. Lee",

year = "1999",

doi = "10.1023/A:1005688627350",

language = "English",

volume = "21",

pages = "1055--1058",

journal = "Biotechnology letters",

issn = "0141-5492",

publisher = "Springer Science and Business Media B.V.",

number = "12",

}

TY - JOUR

T1 - A peptide from corn gluten hydrolysate that is inhibitory toward angiotensin I converting enzyme

AU - Suh, H. J.

AU - Whang, J. H.

AU - Lee, H.

PY - 1999

Y1 - 1999

N2 - A peptide (F4) that inhibits angiotensin I converting enzyme (ACE) was isolated from corn gluten hydrolysate prepared with Pescalase, a serine protease from Bacillus licheniformis. The N-terminal amino acid sequence of F4 was Pro-Ser-Gly-Gln-Tyr-Tyr, having the IC50 value of 0.1 mM. The peptide (F4), at 30 mg kg-1 body weight of rat, antagonized the rat's pressor response to angiotensin I.

AB - A peptide (F4) that inhibits angiotensin I converting enzyme (ACE) was isolated from corn gluten hydrolysate prepared with Pescalase, a serine protease from Bacillus licheniformis. The N-terminal amino acid sequence of F4 was Pro-Ser-Gly-Gln-Tyr-Tyr, having the IC50 value of 0.1 mM. The peptide (F4), at 30 mg kg-1 body weight of rat, antagonized the rat's pressor response to angiotensin I.

KW - Angiotensin converting enzyme

KW - Corn gluten

KW - Peptide inhibitor

KW - Pescalase

KW - Protease

UR - https://www.scopus.com/pages/publications/0033369330

U2 - 10.1023/A:1005688627350

DO - 10.1023/A:1005688627350

M3 - Article

AN - SCOPUS:0033369330

SN - 0141-5492

VL - 21

SP - 1055

EP - 1058

JO - Biotechnology letters

JF - Biotechnology letters

IS - 12

ER -

A peptide from corn gluten hydrolysate that is inhibitory toward angiotensin I converting enzyme

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this