A pilot study of F-18 FP-cit pet imaging in early-onset patients with parkinson’s disease: Parkin versus non-parkin mutation

Kyum Yil Kwon, Seong Beom Koh

    Research output: Contribution to journalArticlepeer-review

    1 Citation (Scopus)

    Abstract

    Striatal dopaminergic dysfunction in early-onset Parkinson’s disease (PD) remains to be further elucidated. Thus, as a preliminary study, we aimed to investigate detailed patterns of dopaminergic depletion in five early-onset PD patients with dynamic N-(3-[(18) F]fluoropropyl)-2-carbomethoxy-3-(4-iodophenyl) nortropane (FP-CIT) positron emission tomography (PET) scans. Two patients with parkin mutation showed more symmetric decrease of dopamine transporter (DAT) density in the putamen, whereas others displayed asymmetric reduction of DAT density in the putamen. Notably, only those with parkin mutation revealed more severe dopaminergic deficits in the anteroventral putamen rather than the posterodoral putamen. Our observation suggests, among PD patients, patients with parkin mutation may exhibit the different pattern of striatal dopaminergic depletion.

    Original languageEnglish
    Pages (from-to)52-56
    Number of pages5
    JournalNeuroQuantology
    Volume16
    Issue number1
    DOIs
    Publication statusPublished - 2018

    Bibliographical note

    Funding Information:
    This work was supported by the Soonchunhyang University Research Fund.

    Publisher Copyright:
    © 2018, Anka Publishers. All rights reserved.

    Keywords

    • Dopamine depletion
    • Early-onset
    • Parkin mutation
    • Parkinson’s disease

    ASJC Scopus subject areas

    • Atomic and Molecular Physics, and Optics
    • Developmental Neuroscience
    • Cognitive Neuroscience

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