A proline-based macrocyclic amide with S4 symmetry

Hee Choon Ahn, Sun Mi Yun, Kihang Choi

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


A new square-shaped macrocyclic amide was prepared from N-(4-amino-2-nitrophenyl)proline (ANPP). The two enantiomers of ANPP were connected in an alternating sequence and then cyclized to the corresponding macrocyclic tetramer with S4 symmetry. In this design, there is a central cavity approximately 7 Å in diameter and rigid aromatic rings and intramolecular hydrogen bonding help to reduce the conformational flexibility of the molecule.

Original languageEnglish
Pages (from-to)10-11
Number of pages2
JournalChemistry Letters
Issue number1
Publication statusPublished - 2008 Jan 5

ASJC Scopus subject areas

  • General Chemistry


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