Abstract
A new square-shaped macrocyclic amide was prepared from N-(4-amino-2-nitrophenyl)proline (ANPP). The two enantiomers of ANPP were connected in an alternating sequence and then cyclized to the corresponding macrocyclic tetramer with S4 symmetry. In this design, there is a central cavity approximately 7 Å in diameter and rigid aromatic rings and intramolecular hydrogen bonding help to reduce the conformational flexibility of the molecule.
Original language | English |
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Pages (from-to) | 10-11 |
Number of pages | 2 |
Journal | Chemistry Letters |
Volume | 37 |
Issue number | 1 |
DOIs | |
Publication status | Published - 2008 Jan 5 |
ASJC Scopus subject areas
- General Chemistry